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master's thesis
Autotransplantacija stanica kože štakora
Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:321072
Kralj, Ines
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Kralj, I. (2014). Autotransplantacija stanica kože štakora (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:321072

Kralj, Ines. "Autotransplantacija stanica kože štakora." Master's thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:321072

Kralj, Ines. "Autotransplantacija stanica kože štakora." Master's thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:321072

Kralj, I. (2014). 'Autotransplantacija stanica kože štakora', Master's thesis, University of Zagreb, Faculty of Science, accessed 03 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:321072

Kralj I. Autotransplantacija stanica kože štakora [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2024 May 03] Available at: https://urn.nsk.hr/urn:nbn:hr:217:321072

I. Kralj, "Autotransplantacija stanica kože štakora", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:321072

Metadata
TitleAutotransplantacija stanica kože štakora
Title (english)Autotransplantation of rat skin cells
AuthorInes Kralj
MentorIvica Rubelj (mentor)
MentorMaja Matulić (mentor)
Committee memberMaja Matulić (predsjednik povjerenstva)
Committee memberIvica Rubelj (član povjerenstva)
Committee memberMirjana Kalafatić (član povjerenstva)
Committee memberInga Marijanović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2014-02-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Starenje je proces koji progresivno zahvaća sve organe i organske sustave. Jedan od najčešće korištenih modela u istraživanju procesa starenja je koža, a u ovom radu je korišten model štakora. Mnoga istraživanja pokazuju da je akumulacija starih stanica glavni uzrok promjena koje nastaju sa starenjem. Da bi testirali ovu hipotezu, potrebno je razviti metodu koja omogućava promjenu sastava stanica kože. Pri tome treba odgovoriti na mnoga pitanja kao što je sposobnost stanica da se nakon reimplantacije ugrade u tkivo štakora, da je broj i gustoća reimplantiranih stanica dostatan da izazove odgovarajući efekt te da njihova učestalost dozvoljava detekciju i analizu. Rezultati su pokazali da se reimplantirane stanice nakon izolacije i obilježavanja efikasno ugrađuju u kožu leđa štakora i to u značajnom postotku od gotovo 6% što u odgovarajućim eksperimentalnim uvjetima otvara mogućnost da se značajno utječe na fiziologiju i teksturu kože. Ova metoda također otvara mogućnost šire eksperimentalne i potencijalno terapeutske primjene
Abstract (english)
Aging is a process that progressively affects all organs and organ systems. One of widely used models in study of aging is skin and in this paper we used rat as a model. Studies have shown accumulation of senescent cells to be the main cause of changes that occur with aging. To test this hypothesis, it is necessary to develop a method for changing composition of skin cells. Many questions need to be answered, such as the ability of cells to incorporate into tissue after reimplantation, whether the number and density of reimplanted cells is sufficient to induce proper effect and whether their frequency allows detection and analysis. Results show that re-implanted cells after isolation and labeling effectively implant in dorsal skin of rats in a significant percentage of almost 6 %. This opens up the possibility of significantly affecting physiology and skin texture but also of wider experimental and potentially therapeutic applications.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:321072
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-26 10:07:47