prikaz prve stranice dokumenta Povezanost polimorfizma Val 108/158Met katehol-o-metil transferaze i kliničkih simptoma posttraumatskog stresnog poremećaja
  Download
PDF 1.41 MB
master's thesis
Povezanost polimorfizma Val 108/158Met katehol-o-metil transferaze i kliničkih simptoma posttraumatskog stresnog poremećaja
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:714505
Medaković, Nikolina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Medaković, N. (2020). Povezanost polimorfizma Val 108/158Met katehol-o-metil transferaze i kliničkih simptoma posttraumatskog stresnog poremećaja (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:714505

Medaković, Nikolina. "Povezanost polimorfizma Val 108/158Met katehol-o-metil transferaze i kliničkih simptoma posttraumatskog stresnog poremećaja." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:714505

Medaković, Nikolina. "Povezanost polimorfizma Val 108/158Met katehol-o-metil transferaze i kliničkih simptoma posttraumatskog stresnog poremećaja." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:714505

Medaković, N. (2020). 'Povezanost polimorfizma Val 108/158Met katehol-o-metil transferaze i kliničkih simptoma posttraumatskog stresnog poremećaja', Master's thesis, University of Zagreb, Faculty of Science, accessed 12 March 2025, https://urn.nsk.hr/urn:nbn:hr:217:714505

Medaković N. Povezanost polimorfizma Val 108/158Met katehol-o-metil transferaze i kliničkih simptoma posttraumatskog stresnog poremećaja [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2025 March 12] Available at: https://urn.nsk.hr/urn:nbn:hr:217:714505

N. Medaković, "Povezanost polimorfizma Val 108/158Met katehol-o-metil transferaze i kliničkih simptoma posttraumatskog stresnog poremećaja", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:714505

Metadata
TitlePovezanost polimorfizma Val 108/158Met katehol-o-metil transferaze i kliničkih simptoma posttraumatskog stresnog poremećaja
Title (english)Association of catehol-o-methyltransferase Val108/158Met polymorphism and clinical symptoms of posttraumatic stress disorder
AuthorNikolina Medaković
MentorGordana Nedić Erjavec (mentor)
MentorMaja Matulić (mentor)
Committee memberMaja Matulić (predsjednik povjerenstva)
Committee memberNada Oršolić (član povjerenstva)
Committee memberMartina Šeruga Musić (član povjerenstva)
Committee memberSofia Ana Blažević (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2020-01-22, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Posttraumatski stresni poremećaj (PTSP) je stresom izazvan poremećaj koji se razvija nakon izlaganja traumatskom događaju. Patofiziologija PTSP-a uključuje poremećaje dopaminergičke funkcije. Funkcionalni polimorfizam rs4680 (Val108/158Met) katehol-o-metil transferaze (COMT) je zbog utjecaja na aktivnost samog enzima, važan za regulaciju degradacije dopamina, posebice u prefrontalnom korteksu. Oblik enzima s valinom se povezuje s njegovom povećanom aktivnošću. Cilj ovog diplomskog rada bilo je... More ispitati povezanost genotipa obzirom na polimorfizam rs4680 gena COMT i težine simptoma PTSP-a procijenjenih kliničkom ljestvicom pozitivnih i negativnih simptoma (PANSS). Studija je uključila 573 muškarca oboljelih od PTSP-a izazavnog ratnim iskustvom kod kojih je težina simptoma prema PANSS-u ovisila o tome jesu li pušači. Istraživanje je pokazalo značajnu povezanost genotipa Met/Met s manjim brojem bodova ostvarenih na PANSS podljestvicama za kogniciju, psihotične simptome i agitaciju kod nepušača te s većim brojem bodova ostvarenih na općoj psihopatološkoj ljestvici kod pušača. Zaključno, polimorfizam rs4680 gena COMT je povezan s težinom pojedinih simptoma procjenjenih prema PANSS-u. Less
Abstract (english)
Posttraumatic Stress Disorder (PTSD) is a stress-related disorder caused by an exposure to a traumatic event. Pathophysiology of PTSD involves dysfunctions in dopaminergic system. A functional polymorphism rs4680 (Val108/158Met) of catechol-o-methyltransferase (COMT), due to its effect on the activity of the enzyme, plays an important role in dopamine degradation, especially in prefrontal cortex. The valine variant is associated with increased enzymatic activity. The aim of this thesis was to... More examine the association of COMT rs4680 genotypes and severity of PTSD symptoms according to positive and negative syndrome scale (PANSS). The study included 573 men with combat related PTSD, whose symptoms' severity according to the PANSS was related to their smoking status. Results indicated a significant association of Met/Met genotype with lower scores on PANSS cognitive, psychosis and excitement subscales in nonsmokers and with higher scores on general psychopathology scale in smokers. In conclusion, the COMT rs4680 polymorphism contributes to the severity of individual PTSD symptoms assessed using the PANSS. Less
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:714505
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-03-16 10:04:38
accessibility

closeAccessibilityrefresh

If you wish to permanently save changes, click on Save, if not - your settings will be reset when you restart the browser.