prikaz prve stranice dokumenta Utjecaj vodene otopine propolisa na oštećenja DNA i lipidnu peroksidaciju prouzročenu aloksanom u miša
Access restricted to students and staff of home institution
master's thesis
Utjecaj vodene otopine propolisa na oštećenja DNA i lipidnu peroksidaciju prouzročenu aloksanom u miša
Zagreb: University of Zagreb, Faculty of Science, 2014. urn:nbn:hr:217:017313
Mikulić, Iva
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Mikulić, I. (2014). Utjecaj vodene otopine propolisa na oštećenja DNA i lipidnu peroksidaciju prouzročenu aloksanom u miša (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:017313

Mikulić, Iva. "Utjecaj vodene otopine propolisa na oštećenja DNA i lipidnu peroksidaciju prouzročenu aloksanom u miša." Master's thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:017313

Mikulić, Iva. "Utjecaj vodene otopine propolisa na oštećenja DNA i lipidnu peroksidaciju prouzročenu aloksanom u miša." Master's thesis, University of Zagreb, Faculty of Science, 2014. https://urn.nsk.hr/urn:nbn:hr:217:017313

Mikulić, I. (2014). 'Utjecaj vodene otopine propolisa na oštećenja DNA i lipidnu peroksidaciju prouzročenu aloksanom u miša', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:017313

Mikulić I. Utjecaj vodene otopine propolisa na oštećenja DNA i lipidnu peroksidaciju prouzročenu aloksanom u miša [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2014 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:017313

I. Mikulić, "Utjecaj vodene otopine propolisa na oštećenja DNA i lipidnu peroksidaciju prouzročenu aloksanom u miša", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2014. Available at: https://urn.nsk.hr/urn:nbn:hr:217:017313

Metadata
TitleUtjecaj vodene otopine propolisa na oštećenja DNA i lipidnu peroksidaciju prouzročenu aloksanom u miša
Title (english)THE EFFECT OF WATER EXTRACT OF PROPOLIS ON DNA DAMAGE AND LIPID PEROXIDATION CAUSED BY ALLOXAN IN MICE
AuthorIva Mikulić
MentorNada Oršolić (mentor)
Committee memberNada Oršolić (predsjednik povjerenstva)
Committee memberJasna Lajtner (član povjerenstva)
Committee memberSandra Radić Brkanac (član povjerenstva)
Committee memberZlatko Liber (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2014-12-10, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Dijabetes melitus (DM) je metabolički poremećaj koji ima visoku stopu rasta. Cilj ovog istraživanja bio je proučiti moguće zaštitne učinke vodene otopine propolisa (VOP) na nastala oštećenja u miševa s dijabetesom prouzročenim aloksanom. Tip 1 dijabetesa induciran je u miševa davanjem aloksana u dozi od 75 mg kg-1 iv. Nakon drugog dana dolazi do povećanja glukoze u serumu životinja obrađenih aloksanom, a desetog dana od iniciranja aloksana vidljiv je znatni pad tjelesne mase u odnosu na zdravu kontrolnu skupinu. VOP (50 mg kg-1) injicirana miševima s dijabetesom tijekom sedam dana bila je učinkovita u održavanju tjelesne mase životinja, preživljenju životinja, povećanju funkcionalne aktivnosti makrofaga peritonealne šupljine i održavanju strukture i funkcije jetrenih stanica dok je učinkovitost na stanice i tkivo bubrega bila neznatna. Rezultati komet testa ukazuju da je VOP smanjila oštećenja DNA u limfocitima periferne krvi uzrokovana oksidativnim stresom te da ima obećavajući učinak na smanjenje negativnih posljedica razvoja dijabetesa.
Abstract (english)
Diabetes mellitus is a metabolic dissorder with high growth rate. The present study was designed to investigate the possible antidiabetic and protective effect of water extract of propolis against alloxan-induced oxidative damage in diabetic mice. Type 1 diabetes was induced in mice by injection alloxan in dose of 75 mg kg-1 bwt iv. After 2 days appears to increase glucose levels in alloxan treated animals, and 10th days of the initiation of alloxan show significant decrease of body weight compared to a healthy control group. Treatment of diabetic mice with water extract of propolis in dose of 50 mg kg-1 for seven days was effective in maintaining the body weight of animals, the survival of animals, increasing the functional activity of macrophages of peritoneal cavity and maintain the structure and function of liver cells while the efficiency of the cells and kidney tissue was insignificant. Additionally comet assay results show that treatment diabetic animals with water extract of propolis reduces the alloxan-induced DNA damage to lymphocytes. The results indicate that aqueous propolis has promising effects in reducing the negative consequences of developing diabetes.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:017313
Study programmeTitle: Experimental Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-26 10:38:37