prikaz prve stranice dokumenta Helical Twist and Rotational Forces in the Mitotic Spindle
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Scientific paper - Review paper
Helical Twist and Rotational Forces in the Mitotic Spindle
Biomolecules, 9 (2019), 4; 132. https://doi.org/10.3390/biom9040132
Tolić, Iva M.; Novak, Maja; Pavin, Nenad

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Tolić, I. M., Novak, M. & Pavin, N. (2019). Helical Twist and Rotational Forces in the Mitotic Spindle. Biomolecules, 9. (4). doi: 10.3390/biom9040132

Tolić, Iva M., et al. "Helical Twist and Rotational Forces in the Mitotic Spindle." Biomolecules, vol. 9, no. 4, 2019. https://doi.org/10.3390/biom9040132

Tolić, Iva M., Maja Novak and Nenad Pavin. "Helical Twist and Rotational Forces in the Mitotic Spindle." Biomolecules 9, no. 4 (2019). https://doi.org/10.3390/biom9040132

Tolić, I. M., Novak, M. and Pavin, N. (2019) 'Helical Twist and Rotational Forces in the Mitotic Spindle', Biomolecules, 9(4). doi: 10.3390/biom9040132

Tolić IM, Novak M, Pavin N. Helical Twist and Rotational Forces in the Mitotic Spindle. Biomolecules [Internet]. 2019 April 01 [cited 2025 March 22];9(4). doi: 10.3390/biom9040132

I. M. Tolić, M. Novak and N. Pavin, "Helical Twist and Rotational Forces in the Mitotic Spindle", Biomolecules, vol. 9, no. 4, April 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:285862. [Accessed: 22 March 2025]

Metadata
Title (english)Helical Twist and Rotational Forces in the Mitotic Spindle
AuthorIva M. Tolić
AuthorMaja Novak
AuthorNenad Pavin
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract (english)
The mitotic spindle segregates chromosomes into two daughter cells during cell division. This process relies on the precise regulation of forces acting on chromosomes as the cell progresses through mitosis. The forces in the spindle are difficult to directly measure using the available experimental techniques. Here, we review the ideas and recent advances of how forces can be determined from the spindle shape. By using these approaches, it has been shown that tension and compression coexist... More along a single kinetochore fiber, which are balanced by a bridging fiber between sister kinetochore fibers. An extension of this approach to three dimensions revealed that microtubule bundles have rich shapes, and extend not simply like meridians on the Earth’s surface but, rather, twisted in a helical manner. Such complex shapes are due to rotational forces, which, in addition to linear forces, act in the spindle and may be generated by motor proteins such as kinesin-5. These findings open new questions for future studies, to understand the mechanisms of rotational forces and reveal their biological roles in cells. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 9, no. 4, 132
e-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom9040132
URN:NBNurn:nbn:hr:217:285862
Publication2019-04-01
ProjectNumber: IP-2014-09-4753
Title (croatian): Oscilatorna genomika citoskeleta
Acronym: OSCITON
Leader: Iva TOLIC
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.mdpi.com/2218-273X/9/4/132
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Public note© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received: 29 January 2019. Revised: 24 March 2019. Accepted: 28 March 2019. Published: 1 April 2019.
Created on2020-07-24 11:30:28
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