prikaz prve stranice dokumenta Teorija nastanka pogrešaka za vrijeme niza staničnih dioba
  Download
PDF 5.3 MB
master's thesis
Teorija nastanka pogrešaka za vrijeme niza staničnih dioba
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:806434
Tomašić, Lucija
University of Zagreb
Faculty of Science
Department of Physics

Institutional repository: Repository of the Faculty of Science

Cite this document

Tomašić, L. (2020). Teorija nastanka pogrešaka za vrijeme niza staničnih dioba (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:806434

Tomašić, Lucija. "Teorija nastanka pogrešaka za vrijeme niza staničnih dioba." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:806434

Tomašić, Lucija. "Teorija nastanka pogrešaka za vrijeme niza staničnih dioba." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:806434

Tomašić, L. (2020). 'Teorija nastanka pogrešaka za vrijeme niza staničnih dioba', Master's thesis, University of Zagreb, Faculty of Science, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:806434

Tomašić L. Teorija nastanka pogrešaka za vrijeme niza staničnih dioba [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:217:806434

L. Tomašić, "Teorija nastanka pogrešaka za vrijeme niza staničnih dioba", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:806434

Metadata
TitleTeorija nastanka pogrešaka za vrijeme niza staničnih dioba
Title (english)Theory for error generation over multiple cell divisions
AuthorLucija Tomašić
MentorNenad Pavin (mentor)
Committee memberNenad Pavin (predsjednik povjerenstva)
Committee memberMatko Glunčić (član povjerenstva)
Committee memberMirko Planinić (član povjerenstva)
Committee memberDanko Radić (član povjerenstva)
Committee memberMatko Milin (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Physics)
Zagreb
Defense date and country2020-07-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Abstract
Pogreške u podjeli kromosoma za vrijeme stanične diobe uzrokuju aneuploidiju, stanje neravnoteže u broju kromosoma. Takvo stanje dovodi do teških bolesti i ubrzava stvaranje tumora. Stoga su otkrivanje podrijetla pogrešaka i njihov dugoročni učinak na stanice ključni za razumijevanje aneuploidije. Da bi se razumjeli mehanizmi koji dovode do velike učestalosti pogrešaka, uveli smo teorijski opis diobe stanica. U pojedinoj diobi, model opisuje mogućnost gubitka kromosoma i brzinu staničnog ciklusa, pri čemu je uzeto u obzir da obje pojave ovise o broju kromosoma u stanici. U modelu se prati veliki broj staničnih dioba gdje se svaka od tih dioba pojedinačno simulira. Na taj način daje se veza između procesa koji se događaju za vrijeme jedne diobe te izgleda cjelokupne populacije stanica. Također, predviđa se broj kromosoma u stanicama kroz generacije i vrste stanica koje prevladavaju nakon velikog broja dioba.
Abstract (english)
Dividing cells that experience chromosome missegregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. This causes severe diseases and promotes tumorigenesis. Hence, the discovery of causes and cellular consequences of missegregation is the key in understanding aneuploidy. To provide insight into important cell mechanisms that drive chromosome instability, we developed theoretical model of cell division. For every single cell division, the model describes the ability of chromosome gain/loss and cell proliferation, where it is taken into consideration that both of these processes depend on the cell karyotype. Model tracks a large number of cell divisions where every single division is simulated separately. In that way, the correlation between the processes in one single cell and the appearance of the whole population is achieved and studied. Likewise, the expected number of chromosomes in cells is predicted.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:806434
Study programmeTitle: Physics; specializations in: Research
Course: Research
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra fizike (magistar/magistra fizike)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-07-16
Terms of useLicence In copyright icon
Created on2020-08-21 13:06:59