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Scientific paper - Original scientific paper
Pivot-and-bond model explains microtubule bundle formation
Physical Review E, 100 (2019), 1; 012403. https://doi.org/10.1103/PhysRevE.100.012403
Prelogović, Marcel; Winters, Lora; Milas, Ana; Tolić, Iva; Pavin, Nenad

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Prelogović, M., Winters, L., Milas, A., Tolić, I. & Pavin, N. (2019). Pivot-and-bond model explains microtubule bundle formation. Physical Review E, 100. (1). doi: 10.1103/PhysRevE.100.012403

Prelogović, Marcel, et al. "Pivot-and-bond model explains microtubule bundle formation." Physical Review E, vol. 100, no. 1, 2019. https://doi.org/10.1103/PhysRevE.100.012403

Prelogović, Marcel, Lora Winters, Ana Milas, Iva Tolić and Nenad Pavin. "Pivot-and-bond model explains microtubule bundle formation." Physical Review E 100, no. 1 (2019). https://doi.org/10.1103/PhysRevE.100.012403

Prelogović, M., et al. (2019) 'Pivot-and-bond model explains microtubule bundle formation', Physical Review E, 100(1). doi: 10.1103/PhysRevE.100.012403

Prelogović M, Winters L, Milas A, Tolić I, Pavin N. Pivot-and-bond model explains microtubule bundle formation. Physical Review E [Internet]. 2019 [cited 2024 November 25];100(1). doi: 10.1103/PhysRevE.100.012403

M. Prelogović, L. Winters, A. Milas, I. Tolić and N. Pavin, "Pivot-and-bond model explains microtubule bundle formation", Physical Review E, vol. 100, no. 1, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:217:834769. [Accessed: 25 November 2024]

Metadata
Title (english)Pivot-and-bond model explains microtubule bundle formation
AuthorMarcel Prelogović
MBZ: 342476
AuthorLora Winters
AuthorAna Milas
AuthorIva Tolić
AuthorNenad Pavin
MBZ: 204800
Author's institutionUniversity of Zagreb
Faculty of Science
(Department of Physics)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Physics
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract (english)
During mitosis, microtubules form a spindle, which is responsible for proper segregation of the genetic material. A common structural element in a mitotic spindle is a parallel bundle, consisting of two or more microtubules growing from the same origin and held together by cross-linking proteins. An interesting question is what are the physical principles underlying the formation and stability of such microtubule bundles. Here we show, by introducing the pivot-and-bond model, that random angular movement of microtubules around the spindle pole and forces exerted by cross-linking proteins can explain the formation of microtubule bundles as observed in our experiments. The model predicts that stable parallel bundles can form in the presence of either passive crosslinkers or plus-end directed motors, but not minus-end directed motors. In the cases where bundles form, the time needed for their formation depends mainly on the concentration of cross-linking proteins and the angular diffusion of the microtubule. In conclusion, the angular motion drives the alignment of microtubules, which in turn allows the cross-linking proteins to connect the microtubules into a stable bundle.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePhysical Review E
Numberingvol. 100, no. 1, 012403
p-ISSN2470-0045
e-ISSN2470-0053
DOIhttps://doi.org/10.1103/PhysRevE.100.012403
URN:NBNurn:nbn:hr:217:834769
Publication2019
Document URLhttps://journals.aps.org/pre/abstract/10.1103/PhysRevE.100.012403
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Public note© 2019 American Physical Society. Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Received 18 April 2017. Revised 24 April 2019. Published 9 July 2019.
Created on2020-08-24 12:17:33