prikaz prve stranice dokumenta Molekularni mehanizmi nastanka karcinoma debelog crijeva
  Download
PDF 317.55 KB
undergraduate thesis
Molekularni mehanizmi nastanka karcinoma debelog crijeva
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:907900
Dragičević, Tea
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Dragičević, T. (2020). Molekularni mehanizmi nastanka karcinoma debelog crijeva (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:907900

Dragičević, Tea. "Molekularni mehanizmi nastanka karcinoma debelog crijeva." Undergraduate thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:907900

Dragičević, Tea. "Molekularni mehanizmi nastanka karcinoma debelog crijeva." Undergraduate thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:907900

Dragičević, T. (2020). 'Molekularni mehanizmi nastanka karcinoma debelog crijeva', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 13 May 2024, https://urn.nsk.hr/urn:nbn:hr:217:907900

Dragičević T. Molekularni mehanizmi nastanka karcinoma debelog crijeva [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2024 May 13] Available at: https://urn.nsk.hr/urn:nbn:hr:217:907900

T. Dragičević, "Molekularni mehanizmi nastanka karcinoma debelog crijeva", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:907900

Metadata
TitleMolekularni mehanizmi nastanka karcinoma debelog crijeva
Title (english)Molecular mechanisms of colorectal cancer development
AuthorTea Dragičević
MentorPetra Korać (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2020, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Karcinom debelog cijeva ubraja se među najčešće karcinome u oba spola te ima veliku stopu smrtnosti. Nastaje iz prethodno postojećih benignih tumora, odnosno adenoma. Uklanjanjem adenoma, bolest je lako prevenirati, a liječenje je moguće ukoliko je do dijagnoze došlo prije posljednjeg stadija, metastazirajućeg karcinoma. U ovom seminaru izložena su dva puta karcinogeneze debelog crijeva, put gubitka heterozigotnosti i put mikrosatelitne nestabilnosti. Oba puta karakterizirana su gubitkom funkcionalnosti gena za tumorske supresore i aktivacijom onkogena te su poremećeni isti signalni putovi u stanici. Mutacije koje dovode do tih događaja razlikuju se ovisno o tipu karcinogeneze.
Abstract (english)
Colorectal cancer is one of the most common cancers in both sexes and has high mortality rate. It arises from previously existing benign tumors, adenomas. By removing the adenomas, the disease could be prevented, and treatment is possible if carcinoma is diagnosed before the last stage, metastatic cancer. Two colon carcinogenesis pathways are showed in this seminar, a pathway based on loss of heterozygosity and a pathway based on microsatellite instability. Both pathways are characterized by loss of tumor suppressor gene function and oncogene activation, and both disrupt the same signaling pathways in the cell. The mutations that lead to these events vary depending on the type of carcinogenesis.
Keywords
Languagecroatian
URN:NBNurn:nbn:hr:217:907900
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-09-03 10:41:31