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master's thesis
Priprava i karakterizacija 2-feniletil-, 3-piridil-, dimetil-izoksazol-4-il, 4-piperidilsulfonilfenil-i tetrahidro-3-furfuril-makrozona, novih konjugata makrolidnih antibiotika
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:954724
Lulić, Ana-Marija
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Lulić, A. M. (2020). Priprava i karakterizacija 2-feniletil-, 3-piridil-, dimetil-izoksazol-4-il, 4-piperidilsulfonilfenil-i tetrahidro-3-furfuril-makrozona, novih konjugata makrolidnih antibiotika (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:954724

Lulić, Ana Marija. "Priprava i karakterizacija 2-feniletil-, 3-piridil-, dimetil-izoksazol-4-il, 4-piperidilsulfonilfenil-i tetrahidro-3-furfuril-makrozona, novih konjugata makrolidnih antibiotika." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:954724

Lulić, Ana Marija. "Priprava i karakterizacija 2-feniletil-, 3-piridil-, dimetil-izoksazol-4-il, 4-piperidilsulfonilfenil-i tetrahidro-3-furfuril-makrozona, novih konjugata makrolidnih antibiotika." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:954724

Lulić, A. M. (2020). 'Priprava i karakterizacija 2-feniletil-, 3-piridil-, dimetil-izoksazol-4-il, 4-piperidilsulfonilfenil-i tetrahidro-3-furfuril-makrozona, novih konjugata makrolidnih antibiotika', Master's thesis, University of Zagreb, Faculty of Science, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:954724

Lulić AM. Priprava i karakterizacija 2-feniletil-, 3-piridil-, dimetil-izoksazol-4-il, 4-piperidilsulfonilfenil-i tetrahidro-3-furfuril-makrozona, novih konjugata makrolidnih antibiotika [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:217:954724

A. M. Lulić, "Priprava i karakterizacija 2-feniletil-, 3-piridil-, dimetil-izoksazol-4-il, 4-piperidilsulfonilfenil-i tetrahidro-3-furfuril-makrozona, novih konjugata makrolidnih antibiotika", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:954724

Metadata
TitlePriprava i karakterizacija 2-feniletil-, 3-piridil-, dimetil-izoksazol-4-il, 4-piperidilsulfonilfenil-i tetrahidro-3-furfuril-makrozona, novih konjugata makrolidnih antibiotika
Title (english)Preparation and characterization of a 2-phenylethyl-, 3-pyridyl-, 3,5-dimethylisoxazol-4-yl, 4-piperidylsulfonylphenyl- and tetrahydro-3-furfuryl-macrozone, new conjugates of macrolide antibiotics
AuthorAna-Marija Lulić
MentorPredrag Novak (mentor)
Committee memberPredrag Novak (predsjednik povjerenstva)
Committee memberVesna Petrović Peroković (član povjerenstva)
Committee memberŽeljka Soldin (član povjerenstva)
Committee memberSanda Rončević (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2020-02-27, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Makrolidi su velika klasa antibiotika koje karakterizira širok spektar antibakterijskog djelovanja i slična kemijska struktura. Građeni su od makrolaktonskog prstena na koji mogu biti vezane šećerne jedinice, najčešće desozamin i kladinoza. Zbog pretjerane upotrebe antibiotika u medicini, veterinarstvu i uzgoju biljaka, bakterije su razvile mehanizme otpornosti, a potencijalno rješenje ovog problema je sinteza i dizajn novih makrolida kemijskom modifikacijom već postojećih. Makrozoni su nova klasa derivata makrolidnih antibiotika u kojima je na poziciju 9a makrolaktonskog prstena vezana molekula tiosemikarbazona preko molekule poveznice. Sintetizirani su 2-feniletil-, 3-piridil-, 3,5-dimetilizoksazol-4-il-, 4-piperidilsulfonilfenil- i tetrahidro-3-furfuril-makrozon u tri reakcijska koraka. Dobiveni makrozoni pročišćeni su kromatografijom na koloni, a zatim su strukturno karakterizirani jednod- i dvodimenzijskom spektroskopijom NMR.
Abstract (english)
Macrolides are a large class of antibiotics known for a wide range of antibacterial activity and similar chemical structure. Their structure is made up of a macrolactone ring to which sugar units may be attached, most commonly desosaminosis and cladinosis. Due to the overuse of antibiotics in medicine, veterinary medicine and cultivation of plants, bacteria have developed resistance mechanisms. Potential solution to this problem is the synthesis and design of new macrolides by chemical modification of existing ones. Macrozones are a new class of macrolide antibiotic derivatives in which a thiosemicarbazone molecule is attached to the position 9a of the macrolactone ring via linkage molecule. 2-phenylethyl-, 3-pyridyl-, 3,5-dimethylisoxazol-4-yl-, 4-piperidylsulfonylphenyl- and tetrahydro-3-furfuryl-macrozone were synthesized in three reaction steps. The resulting macrozones were purified by column chromatography and structurally characterized by one and two-dimensional NMR spectroscopy.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:954724
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-09-07 12:33:26