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undergraduate thesis
Norvalin u prirodnim spojevima, peptidima i proteinima
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:939437
Škibola, Zara
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Škibola, Z. (2020). Norvalin u prirodnim spojevima, peptidima i proteinima (Undergraduate thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:939437

Škibola, Zara. "Norvalin u prirodnim spojevima, peptidima i proteinima." Undergraduate thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:939437

Škibola, Zara. "Norvalin u prirodnim spojevima, peptidima i proteinima." Undergraduate thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:939437

Škibola, Z. (2020). 'Norvalin u prirodnim spojevima, peptidima i proteinima', Undergraduate thesis, University of Zagreb, Faculty of Science, accessed 17 June 2024, https://urn.nsk.hr/urn:nbn:hr:217:939437

Škibola Z. Norvalin u prirodnim spojevima, peptidima i proteinima [Undergraduate thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2024 June 17] Available at: https://urn.nsk.hr/urn:nbn:hr:217:939437

Z. Škibola, "Norvalin u prirodnim spojevima, peptidima i proteinima", Undergraduate thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:939437

Metadata
TitleNorvalin u prirodnim spojevima, peptidima i proteinima
Title (english)Norvaline in natural products, peptides and proteins
AuthorZara Škibola
MentorAleksandra Maršavelski (mentor)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2020-09-14, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Neobične (ili rijetko korištene) aminokiseline su prisutne u nekolicini staničnih peptida. Često su uključene u peptidne antibiotike proizvedene ne-ribosomalnom sintezom, a u drugim slučajevima do njihove ribosomalne ugradnje dolazi prilikom ekspresije heterolognih proteina u bakterijskim stanicama. Norvalin je jedna od takvih, nekanonskih aminokiselina koji može biti ugrađen u proteine na leucinske pozicije. Razvijene su i metode koje omogućuju ciljanu ugradnju nekanonskih aminokiselina u proteine te tako povećavaju strukturalnu različitost proteinskih bočnih ogranaka. Proširivanjem seta od 20 aminokiselina uporabom nekanonskih analoga, omogućeno je sustavnije istraživanje različitih fizikalno-kemijskih fenomena. Osim korištenja u fundamentalnim istraživanjima, veliki je interes i za ugradnju neproteinogenih aminokiselina u prirodne spojeve i peptide za terapeutsku uporabu kako bi se poboljšala njihova svojstva i učinkovitost. Korištenjem ovakvog proširenog genetičkog koda pružaju se mogućnosti za stvaranje modelnih proteina te proteina s poboljšanim ili potpuno novim svojstvima.
Abstract (english)
Unusual (or infrequently occurring) amino acids are present in a number of cellular peptides. They are often included in peptide antibiotics produced by nonribosomal synthesis, in other cases, misincorporation of these amino acids into proteins by the ribosomes occurs when heterologous proteins are expressed in bacterial cells. Norvaline is one of those noncanonical amino acids that can be incorporated in proteins on leucine positions. Methods that allow site-specific incorporation of noncanonical amino acids were developed; thereby increasing the structural diversity of amino acid residues used in proteins. By expanding the natural ocurring set of 20 proteinogenic amino acids, more systematic research of different physicochemical phenomena is enabled. Except for its use in fundamental research, there is a great interest in incorporation of nonproteinogenic amino acids in natural products and peptides for therapeutic use. Usage of this expanded genetic code offers possibilities for designing model peptides and proteins with enhanced or novel properties.
Keywords
Languagecroatian
URN:NBNurn:nbn:hr:217:939437
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-09-15 11:57:33