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master's thesis
Spektrofotometrijsko i spektrofluorimetrijsko određivanje prazikvantela
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:032373
Matijević, Tena
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Matijević, T. (2020). Spektrofotometrijsko i spektrofluorimetrijsko određivanje prazikvantela (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:032373

Matijević, Tena. "Spektrofotometrijsko i spektrofluorimetrijsko određivanje prazikvantela." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:032373

Matijević, Tena. "Spektrofotometrijsko i spektrofluorimetrijsko određivanje prazikvantela." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:032373

Matijević, T. (2020). 'Spektrofotometrijsko i spektrofluorimetrijsko određivanje prazikvantela', Master's thesis, University of Zagreb, Faculty of Science, accessed 22 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:032373

Matijević T. Spektrofotometrijsko i spektrofluorimetrijsko određivanje prazikvantela [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2024 November 22] Available at: https://urn.nsk.hr/urn:nbn:hr:217:032373

T. Matijević, "Spektrofotometrijsko i spektrofluorimetrijsko određivanje prazikvantela", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:032373

Metadata
TitleSpektrofotometrijsko i spektrofluorimetrijsko određivanje prazikvantela
Title (english)Spectrophotometric and spectrofluorimetric determination of praziquantel
AuthorTena Matijević
MentorNives Galić (mentor)
Committee memberNives Galić (predsjednik povjerenstva)
Committee memberInes Primožič (član povjerenstva)
Committee memberDubravka Matković-Čalogović (član povjerenstva)
Committee memberSnežana Miljanić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2020-09-10, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Prazikvantel (PZQ) je antihelmintik koji prema biofarmaceutskom sustavu klasifikacije spada u klasu II (niska topljivost, visoka permeabilnost). Međutim, utvrđeno je da mu se topljivost u biorelevantnom mediju povećava ukoliko je u kompleksu s ciklodekstrinom. Utjecaj β-ciklodekstrina i tri njegova derivata (hidroksipropil-β-ciklodekstrin, sulfobutileter-β-ciklodekstrin te nasumično metiliran β-ciklodekstrin) na topljivost PZQ u vodi istražen je u sklopu ovog diplomskog rada. Prazikvantel je u vodi kvantitativno određen validiranim UV/Vis spektrofotometrijskim i spektrofluorimetrijskim metodama. Dobiveni rezultati su uspoređeni s onima iz diplomskog rada Petre Tagliaretti u kojem su analizirani identični sustavi, a količina PZQ je određena tekućinskom kromatografijom visoke djelotvornosti.
Abstract (english)
Praziquantel (PZQ) is an anthelmintic which is categorized as a class II compound (low solubility, high permeability) according to the Biopharmaceutical Classification System. However, its solubility in biorelevant media was found to increase if it was complexed by cyclodextrins. Effect of β-cyclodextrin and three of its derivatives (hydroxypropyl-β-cyclodextrin, sulfobutylether-β-cyclodextrin and randomly methylated β-cyclodextrin) on the solubility of PZQ in water was studied in this thesis. Praziquantel in water was quantitatively determined by validated UV/Vis spectrophotometric and spectrofluorimetric methods. The obtained results were compared with those presented in Petra Tagliaretti's thesis, in which identical systems were analyzed and the amount of PZQ was determined by high performance liquid chromatography.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:032373
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-09-10
Terms of useLicence In copyright icon
Created on2020-09-24 10:48:09