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master's thesis
Sinteza i karakterizacija kvaternih 10,11-dihidro derivata cinhonidina i cinhonina
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:916669
Debanić, Barbara
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Debanić, B. (2020). Sinteza i karakterizacija kvaternih 10,11-dihidro derivata cinhonidina i cinhonina (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:916669

Debanić, Barbara. "Sinteza i karakterizacija kvaternih 10,11-dihidro derivata cinhonidina i cinhonina." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:916669

Debanić, Barbara. "Sinteza i karakterizacija kvaternih 10,11-dihidro derivata cinhonidina i cinhonina." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:916669

Debanić, B. (2020). 'Sinteza i karakterizacija kvaternih 10,11-dihidro derivata cinhonidina i cinhonina', Master's thesis, University of Zagreb, Faculty of Science, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:916669

Debanić B. Sinteza i karakterizacija kvaternih 10,11-dihidro derivata cinhonidina i cinhonina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:916669

B. Debanić, "Sinteza i karakterizacija kvaternih 10,11-dihidro derivata cinhonidina i cinhonina", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:916669

Metadata
TitleSinteza i karakterizacija kvaternih 10,11-dihidro derivata cinhonidina i cinhonina
Title (english)Synthesis and characterisation of quaternary 10,11-dihydro derivatives of cinchonidine and cinchonine
AuthorBarbara Debanić
MentorInes Primožič (mentor)
Committee memberInes Primožič (predsjednik povjerenstva)
Committee memberIva Juranović Cindrić (član povjerenstva)
Committee memberBiserka Prugovečki (član povjerenstva)
Committee memberĐani Škalamera (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2020-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U okviru ovog diplomskog rada opisana je priprava dva derivata Cinhona alkaloida: 10,11-dihidrocinhonina i 10,11-dihidrocinhonidina reakcijom katalitičke hidrogenacije komercijalno dostupnih cinhonina i cinhonidina. Dobiveni dihidro derivati su potom kvaternizirani različito supstituiranim benzilnim bromidima te je pripravljeno 16 novih spojeva. Spojevi se razlikuju po supstituentima na benzenskom prstenu benzilne skupine i svi sadrže jedan ili više atoma fluora (uključujući trifluormetilnu i trifluormetoksi-skupine) u meta i para položaju. Identifikacija i kontrola čistoće pripravljenih spojeva provedena je analitičkim postupcima koji uključuju IR i NMR (1H i 13C) spektroskopiju. Derivatima je također određeno specifično optičko zakretanje.
Abstract (english)
The preparation of two alkaloid derivatives, 10,11-dihydrocinchonine and 10,11-dihydrocinchonidine, by catalytic hydrogenation of commercially available cinchonine and cinchonidine is described in this thesis. The resulting dihydro derivatives are then quaternized with various substituted benzyl bromides, and 16 new compounds were prepared. Substituents on the benzene ring of the benzyl moiety were changed from a fluorine atom to trifluoromethyl and trifluoromethoxy groups in meta and para positions. Identification and purity control of the prepared compounds was performed by analytical methods including IR and 1D and 2D NMR spectroscopy. The specific optical rotations were also determined for all synthesized pseudoenantiomers.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:916669
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-09-25
Terms of useLicence In copyright icon
Created on2020-10-07 10:14:55