prikaz prve stranice dokumenta Utjecaj halogenidnih iona na kristalizaciju te molekulsku i kristalnu strukturu bakrovog(II), niklovog(II) i kobaltovog(II) derivata ljudskog inzulina
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master's thesis
Utjecaj halogenidnih iona na kristalizaciju te molekulsku i kristalnu strukturu bakrovog(II), niklovog(II) i kobaltovog(II) derivata ljudskog inzulina
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:727797
Gomaz, Boris
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Gomaz, B. (2020). Utjecaj halogenidnih iona na kristalizaciju te molekulsku i kristalnu strukturu bakrovog(II), niklovog(II) i kobaltovog(II) derivata ljudskog inzulina (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:727797

Gomaz, Boris. "Utjecaj halogenidnih iona na kristalizaciju te molekulsku i kristalnu strukturu bakrovog(II), niklovog(II) i kobaltovog(II) derivata ljudskog inzulina." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:727797

Gomaz, Boris. "Utjecaj halogenidnih iona na kristalizaciju te molekulsku i kristalnu strukturu bakrovog(II), niklovog(II) i kobaltovog(II) derivata ljudskog inzulina." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:727797

Gomaz, B. (2020). 'Utjecaj halogenidnih iona na kristalizaciju te molekulsku i kristalnu strukturu bakrovog(II), niklovog(II) i kobaltovog(II) derivata ljudskog inzulina', Master's thesis, University of Zagreb, Faculty of Science, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:727797

Gomaz B. Utjecaj halogenidnih iona na kristalizaciju te molekulsku i kristalnu strukturu bakrovog(II), niklovog(II) i kobaltovog(II) derivata ljudskog inzulina [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:727797

B. Gomaz, "Utjecaj halogenidnih iona na kristalizaciju te molekulsku i kristalnu strukturu bakrovog(II), niklovog(II) i kobaltovog(II) derivata ljudskog inzulina", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:727797

Metadata
TitleUtjecaj halogenidnih iona na kristalizaciju te molekulsku i kristalnu strukturu bakrovog(II), niklovog(II) i kobaltovog(II) derivata ljudskog inzulina
Title (english)Influence of halide ions on crystallization and molecular and crystal structure of copper(II), nickel(II) and cobalt(II) derivatives of human insulin
AuthorBoris Gomaz
MentorBiserka Prugovečki (mentor)
MentorIvana Kekez (komentor)
Committee memberBiserka Prugovečki (predsjednik povjerenstva)
Committee memberJasmina Rokov Plavec (član povjerenstva)
Committee memberDavor Kovačević (član povjerenstva)
Committee memberDubravka Matković-Čalogović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2020-09-24, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Kristalizacijom inzulina s metalnim ionima (bakar(II), nikal(II) i kobalt(II)) u prisustvu različitih koncentracija halogenidnih iona (Cl-, Br- i I-)dobiveno je 28 različitih jediničnih kristala koji su analizirani rendgenskom difrakcijom. Riješene su kristalne strukture triju derivata inzulina. Niklov(II) derivat inzulina kristaliziran u prisustvu bromidnih iona (c = 0,898 mol dm-3) kristalizira u prostornoj grupi H32 s jednim monomerom inzulina u asimetričnoj jedinici dok u prisustvu niže koncentracije bromidnih iona (c = 0,148 mol dm-3) kristalizira u prostornoj grupi H3 s jednim dimerom inzulina u asimetričnoj jedinici. Kobaltov(II) derivat inzulina kristaliziran u prisustvu kloridnih iona (c = 0,248 mol dm-3) također kristalizira u prostornoj grupi H3, ali s dva dimera inzulina u asimetričnoj jedinici. U svim analiziranim strukturama heksameri inzulina su T6 forme te sadrže dva metalna iona (Ni/Co) koordinirana s tri dušikova atoma iz simetrijski ovisnih molekula histidina i tri kisikova atoma iz tri molekule vode, ali su različite stabilnosti.
Abstract (english)
Crystallization of insulin with metal ions (copper(II), nickel(II) and cobalt(II)) in the presence of different concentrations of halide ions (Cl-, Br- i I-) yielded 28 different single crystals which were analyzed by X-ray diffraction method. The crystal structures of three insulin derivatives were solved. Nikel(II) insulin derivative crystallized in the presence of bromide ions (c = 0,898 mol dm-3) crystallizes in the H32 space group with one insulin monomer in the asymmetric unit, while in the presence of lower concentration of bromide ions (c = 0,148 mol dm-3) crystallizes in the H3 space group with one dimer in the asymmetric unit. The cobalt(II) insulin derivative crystallized in the presence of chloride ions (c = 0,248 mol dm-3) also crystallizes in the H3 space group, but with two dimers in the asymmetric unit. In all analyzed structures, insulin hexamers are in T6 form and two metal ions (Ni/Co) are octahedrally coordinated by three symmetry-related nitrogen atoms of three histidine molecules and three oxygen atoms from three water molecules, but with different stability.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:727797
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-09-24
Terms of useLicence In copyright icon
Created on2020-10-07 11:19:47