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doctoral thesis
Modulacija crijevnoga mikrobioma kvercetinom u štakorskomu modelu Alzheimerove bolesti
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:707173
Kukolj, Marina
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Kukolj, M. (2020). Modulacija crijevnoga mikrobioma kvercetinom u štakorskomu modelu Alzheimerove bolesti (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:707173

Kukolj, Marina. "Modulacija crijevnoga mikrobioma kvercetinom u štakorskomu modelu Alzheimerove bolesti." Doctoral thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:707173

Kukolj, Marina. "Modulacija crijevnoga mikrobioma kvercetinom u štakorskomu modelu Alzheimerove bolesti." Doctoral thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:707173

Kukolj, M. (2020). 'Modulacija crijevnoga mikrobioma kvercetinom u štakorskomu modelu Alzheimerove bolesti', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:707173

Kukolj M. Modulacija crijevnoga mikrobioma kvercetinom u štakorskomu modelu Alzheimerove bolesti [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:707173

M. Kukolj, "Modulacija crijevnoga mikrobioma kvercetinom u štakorskomu modelu Alzheimerove bolesti", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:707173

Metadata
TitleModulacija crijevnoga mikrobioma kvercetinom u štakorskomu modelu Alzheimerove bolesti
Title (english)Modulation of intestinal microbiome with quercetin in the rat model of Alzheimer's disease
AuthorMarina Kukolj
MentorNada Oršolić (mentor)
Committee memberJasna Hrenović (predsjednik povjerenstva)
Committee memberRomana Gračan (član povjerenstva)
Committee memberSvjetlana Terzić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2020-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		57 - Biological sciences. Physical anthropology. Biodiversity
Abstract
Cilj rada bio je ustanoviti poveznicu između narušene osi crijevna mikrobiota-crijeva-mozak (GBA) i primjene funkcionalne hrane u održavanju mikrobne homeostaze i funkcije središnjeg živčanog sustava (CNS-a) u štakorskomu modelu Alzheimerove bolest (AD). Rezultati ukazuju da kvercetin, kao funkcionalna sastavnica hrane, uspješno modulira narušene homeostatske i neuropatološke posljedice primjene aluminijevog klorida i D-galaktoze tijekom 28 dana: uspješno regulira razinu oksidacijskog stresa i antioksidanata vodeći do izravne zaštite neurona; inhibirajući aktivnost AChE smanjuje agregaciju Aβ; održava razinu BDNF povećavajući preživljavanje, rast i diferencijaciju živčanih stanica; smanjuje razinu nitrita, aktivnosti arginaze i proupalnih citokina regulirajući imunoreaktivnost mikroglija stanica i neuroupalu; održava mikrobnu homeostazu i cjelovitost crijevnoga endotela vodeći očuvanju homeostatskih procesa u CNS-u. Višestruki učinci kvercetina potvrđuju da kvercetin jest funkcionalna sastavnica hrane te može biti primijenjen kao alternativni ne-farmaceutski pristup u održavanju zdravlja i dobrobiti crijeva. Promicanjem crijevne mikrobne homeostaze kvercetin omogućuje održavanje funkcionalnosti CNS-a te cjelokupnog organizma.
Abstract (english)
The aim of this dissertation was to find a link between impaired intestinal microbiome-gut-brain axis (GBA) and the use of quercetin, a functional food component, in maintaining microbial homeostasis and function of central nervous system (CNS) in the rat model of Alzheimer's disease (AD). The results indicate that quercetin successfully modulated impaired homeostatic and neuropathological consequences of aluminium chloride and D-galactose administration over 28 days: it directly protected the neurons by regulating the level of oxidative stress and antioxidants; reduced Aβ aggregation by inhibiting AChE activity; increased nerve cell survival, growth, and differentiation by maintaining BDNF levels; regulated the immunoreactivity of microglia and neuroinflammation by reducing the nitrite levels, arginase activity and proinflammatory cytokines; and maintained microbial homeostasis and intestinal endothelial integrity. The multiple effects confirm that quercetin can be applied as an alternative non-pharmaceutical approach in maintaining intestinal health and microbial homeostasis, which consequently affect the functioning of the CNS and the whole organism.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:707173
Promotion2020
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-09-28
Terms of useLicence In copyright icon
Created on2020-10-08 08:56:40