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master's thesis
Priprava i karakterizacija kiralnih derivata kinuklidin-3-ola
Zagreb: University of Zagreb, Faculty of Science, 2020. urn:nbn:hr:217:489898
Brekalo, Iva
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

Cite this document

Brekalo, I. (2020). Priprava i karakterizacija kiralnih derivata kinuklidin-3-ola (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:489898

Brekalo, Iva. "Priprava i karakterizacija kiralnih derivata kinuklidin-3-ola." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:489898

Brekalo, Iva. "Priprava i karakterizacija kiralnih derivata kinuklidin-3-ola." Master's thesis, University of Zagreb, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:217:489898

Brekalo, I. (2020). 'Priprava i karakterizacija kiralnih derivata kinuklidin-3-ola', Master's thesis, University of Zagreb, Faculty of Science, accessed 20 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:489898

Brekalo I. Priprava i karakterizacija kiralnih derivata kinuklidin-3-ola [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2020 [cited 2024 November 20] Available at: https://urn.nsk.hr/urn:nbn:hr:217:489898

I. Brekalo, "Priprava i karakterizacija kiralnih derivata kinuklidin-3-ola", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:217:489898

Metadata
TitlePriprava i karakterizacija kiralnih derivata kinuklidin-3-ola
Title (english)Preparation and characterisation of chiral quinuclidin-3-ol derivatives
AuthorIva Brekalo
MentorInes Primožič (mentor)
Committee memberInes Primožič (predsjednik povjerenstva)
Committee memberIva Juranović Cindrić (član povjerenstva)
Committee memberBiserka Prugovečki (član povjerenstva)
Committee memberĐani Škalamera (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2020-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
U okviru ovog rada opisana je rezolucija racemičnog kinuklidin-3-ola pomoću D- i L-vinske kiseline te priprava njegovih racemičnih i enantiomerno čistih kvaternih soli. Kvaternizacija kinuklidin-3-ola provodila se uz pomoć alkil-halogenida različite duljine ugljikovodičnog lanca i to C8-C16 za sintezu monomera (petnaest spojeva) te C8-C10 za sintezu dimera (šest spojeva). Identifikacija spojeva provedena je klasičnim analitičkim postupcima koji uključuju infracrvenu spektroskopiju i 1D i 2D spektroskopiju NMR. Čistoća dobivenih spojeva kontrolirana je tankoslojnom kromatografijom (TSK), a enantiomerna čistoća mjerenjem optičkog zakretanja.
Abstract (english)
In the scope of this work, the resolution of racemic quinuclidin-3-ol using D- and L-tartaric acid and the preparation of its racemic and enantiomerically pure quaternary salts are described. Quaternization of quinuflicin-3-ol was performed using alkyl-halides of different lengths of hydrocarbon chain C8-C16 for monomer synthesis (15 compounds) and C8-C10 for dimer synthesis (6 compounds). Compound identification was performed by classical analytical methods involving infrared spectroscopy and 1D and 2D NMR spectroscopy. The purity of the obtained compounds was controlled by thin-layer chromatography (TLC), and the enantiomeric purity by measuring the optical rotation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:489898
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2022-09-25
Terms of useLicence In copyright icon
Created on2020-10-14 12:35:24