prikaz prve stranice dokumenta Uloga polimorfizma gena za katehol-O- metiltransferazu i dopaminski transporter u alkoholizmu
Access restricted to students and staff of home institution
master's thesis
Uloga polimorfizma gena za katehol-O- metiltransferazu i dopaminski transporter u alkoholizmu
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:614191
Nižić, Petra
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Nižić, P. (2013). Uloga polimorfizma gena za katehol-O- metiltransferazu i dopaminski transporter u alkoholizmu (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:614191

Nižić, Petra. "Uloga polimorfizma gena za katehol-O- metiltransferazu i dopaminski transporter u alkoholizmu." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:614191

Nižić, Petra. "Uloga polimorfizma gena za katehol-O- metiltransferazu i dopaminski transporter u alkoholizmu." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:614191

Nižić, P. (2013). 'Uloga polimorfizma gena za katehol-O- metiltransferazu i dopaminski transporter u alkoholizmu', Master's thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:614191

Nižić P. Uloga polimorfizma gena za katehol-O- metiltransferazu i dopaminski transporter u alkoholizmu [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:614191

P. Nižić, "Uloga polimorfizma gena za katehol-O- metiltransferazu i dopaminski transporter u alkoholizmu", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:614191

Metadata
TitleUloga polimorfizma gena za katehol-O- metiltransferazu i dopaminski transporter u alkoholizmu
Title (english)The role of catechol-O-methyltransferase and dopamine transporter gene polymorphisms in alcoholism
AuthorPetra Nižić
MentorNela Pivac (mentor)
MentorDubravka Hranilović (sumentor)
Committee memberDubravka Hranilović (predsjednik povjerenstva)
Committee memberNela Pivac (član povjerenstva)
Committee memberMirjana Pavlica (član povjerenstva)
Committee memberInga Marijanović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013-09-16, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Alkoholizam je psihijatrijski poremećaj kompleksne etiologije koji nastaje zbog različitih genetičkih i okolišnih čimbenika te njihove međusobne interakcije. Iako su geni dopaminergičkog sustava povezani s alkoholizmom, rezultati istraživanja o povezanosti alkoholizma i polimorfizma zamjene jedne baze Val108/158Met gena za katehol-O-metil transferazu (COMT), ili polimorfizma varijabilnog broja ponavljanja u 15. eksonu gena za dopaminski transporter (DAT1) su oprečni. Cilj ovog rada bio je odrediti postoji li u hrvatskoj populaciji povezanost alkoholizma i specifičnih fenotipova vezanih za alkoholizam s polimorfizmima gena COMT i DAT1. Genotipizirano je 376 ovisnika o alkoholu i 397 zdravih osoba. Nije uočena značajna razlika u učestalosti genotipova i alela COMT i DAT1 između ovisnika o alkoholu i zdravih osoba. Rezultati pokazuju da nije potvrđena hipoteza o utjecaju navedenih polimorfizama na razvoj alkoholizma, ali je pronađena njihova veza s dobi početka prekomjerne uporabe alkohola. Također je pronađena i povezanost polimorfizma COMT s pokušajem suicida, te suicidalnim ponašanjem.
Abstract (english)
Alcoholism is complex psychiatric disorder which develops as a product of genetic and environmental factors and their interaction. Although genes of the dopaminergic system are associated with alcoholism, studies show contradictory data on association of alcoholism with catechol-O-methyltransferase (COMT) Val108/158Met polymorphism or with variable number of tandem repeats polymorphism in the 15th exon of dopamine transporter gene (DAT1). The aim of this study was to determine whether polymorphisms in COMT and DAT1 genes are associated with alcoholism and alcoholism-related phenotypes in Croatian population. The study included 376 subjects with alcohol dependence and 397 control subjects. There was no significant difference in the frequency of the COMT and DAT1 genotypes and alleles between alcoholics and healthy subjects. The results failed to confirm the hypothesis of the association between alcoholism and COMT and DAT1 polymorphisms, but identified their association with beginning of the excessive alcohol use. Also, a relationship between COMT polymorphism and suicidal behavior and suicide attempt was found.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:614191
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-27 11:58:40