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master's thesis
Povezanost polimorfizama gena za leptin i leptinski receptor s pretilošću u ljudi
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:656996
Petrić, Sara
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Petrić, S. (2013). Povezanost polimorfizama gena za leptin i leptinski receptor s pretilošću u ljudi (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:656996

Petrić, Sara. "Povezanost polimorfizama gena za leptin i leptinski receptor s pretilošću u ljudi." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:656996

Petrić, Sara. "Povezanost polimorfizama gena za leptin i leptinski receptor s pretilošću u ljudi." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:656996

Petrić, S. (2013). 'Povezanost polimorfizama gena za leptin i leptinski receptor s pretilošću u ljudi', Master's thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:656996

Petrić S. Povezanost polimorfizama gena za leptin i leptinski receptor s pretilošću u ljudi [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:656996

S. Petrić, "Povezanost polimorfizama gena za leptin i leptinski receptor s pretilošću u ljudi", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:656996

Metadata
TitlePovezanost polimorfizama gena za leptin i leptinski receptor s pretilošću u ljudi
Title (english)Association of leptin gene and leptin receptor polymorphisms with obesity in humans
AuthorSara Petrić
MentorMarijana Peričić Salihović (mentor)
Committee memberMarijana Peričić Salihović (predsjednik povjerenstva)
Committee memberInga Marijanović (član povjerenstva)
Committee memberDomagoj Đikić (član povjerenstva)
Committee memberAna Galov (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013-12-09, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Pretilost je složeni poremećaj koji nastaje zbog neravnoteže unosa i potrošnje energije, te je bitan rizični faktor za velik broj kroničnih bolesti. Signalni put leptina jedan je od najbitnijih puteva uključenih u regulaciju energetske homeostaze. Leptin je hormon koji se primarno izlučuje u bijelom masnom tkivu. Leptinski receptori se nalaze u mnogim organskim sustavima, ali posebno su važni oni u hipotalamusu gdje reguliraju energetsku homeostazu (unos hrane i potrošnju energije). Opisani su brojni polimorfizmi u genima za leptin i leptinski receptor kod ljudi, te se za neke smatra da su povezani s razvojem pretilosti. U ovom istraživanju se na 375 uzoraka DNA Hrvatskih Roma ispitala povezanost polimorfizama Gln223Arg i Lys109Arg leptinskog receptora i 27 polimorfizama dijela promotorske regije leptinskog gena s pretilošću. Samo je polimorfizam Lys109Arg (genotip AA) pokazao povezanost s prekomjernom težinom kod muškaraca, dok polimorfizmi promotorske regije leptina i polimorfizam Gln223Arg nisu pokazali nikakvu povezanost s pretilošću.
Abstract (english)
Obesity is complex disorder which develops when energy intake exceeds energy utilization. It increases the risk for a variety of chronic diseases. The leptin-signalling pathway is considered one of the most important routes involved in energy homeostasis. Leptin is a hormone produced predominantly by the white adipose tissue. Leptin receptor is expressed in many tissues, but it is particularly important in the hypothalamus, where it regulates energy homeostasis (food intake and energy expenditure). Many leptin and leptin receptor genes polymorphisms have been investigated, and some of them are candidates for association with obesity. In this study, leptin receptor polymorphisms Gln223Arg and Lys109Arg, and 27 leptin promoter polymorphisms have been analysed for association with obesity, in 375 Croatian Roma DNA samples. The results indicate that there is no association between Gln223Arg, and leptin promoter polymorphisms with obesity. However, Lys109Arg AA genotype is associated with overweight in men.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:656996
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-27 12:16:29