prikaz prve stranice dokumenta Analiza polimorfizama gena VEGF u sporadičnim karcinomima debelog crijeva
Access restricted to students and staff of home institution
master's thesis
Analiza polimorfizama gena VEGF u sporadičnim karcinomima debelog crijeva
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:936430
Ponoš, Josipa
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Ponoš, J. (2013). Analiza polimorfizama gena VEGF u sporadičnim karcinomima debelog crijeva (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:936430

Ponoš, Josipa. "Analiza polimorfizama gena VEGF u sporadičnim karcinomima debelog crijeva." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:936430

Ponoš, Josipa. "Analiza polimorfizama gena VEGF u sporadičnim karcinomima debelog crijeva." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:936430

Ponoš, J. (2013). 'Analiza polimorfizama gena VEGF u sporadičnim karcinomima debelog crijeva', Master's thesis, University of Zagreb, Faculty of Science, accessed 18 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:936430

Ponoš J. Analiza polimorfizama gena VEGF u sporadičnim karcinomima debelog crijeva [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 November 18] Available at: https://urn.nsk.hr/urn:nbn:hr:217:936430

J. Ponoš, "Analiza polimorfizama gena VEGF u sporadičnim karcinomima debelog crijeva", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:936430

Metadata
TitleAnaliza polimorfizama gena VEGF u sporadičnim karcinomima debelog crijeva
Title (english)Analysis of VEGF polymorphisms in sporadic colon cancer
AuthorJosipa Ponoš
MentorTamara Čačev (mentor)
MentorMaja Matulić (mentor)
Committee memberMaja Matulić (predsjednik povjerenstva)
Committee memberTamara Čačev (član povjerenstva)
Committee memberMarina Ilakovac Kveder (član povjerenstva)
Committee memberInga Marijanović (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013-02-06, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Karcinom debelog crijeva nastaje kao rezultat stupnjevitog procesa akumulacije genetičkih i epigenetičkih promjena u nizu onkogena i tumor supresorskih gena. Angiogeneza je proces neophodan za nastanak i napredovanje tumora, a faktor rasta vaskularnog endotela (VEGF) je jedna od ključnih molekula u ovom procesu. Budući da na razinu ekspresije gena VEGF utječu i regulatorni SNP polimorfizmi, cilj ovog istraživanja bio je ispitati ulogu ovih polimorfizama u sklonosti obolijevanju i preživljenju od sporadičnog karcinoma debelog crijeva. U analizi polimorfizama VEGF -634 G/C i VEGF +936 C/T korištena je metoda TaqManTM real-time PCR. Nije opažena statistički značajna razlika u raspodjeli pojedinih genotipova i haplotipova u skupini oboljelih od sporadičnog karcinoma debelog crijeva u odnosu na zdravu populaciju. Analiza preživljenja je pokazala da su oboljeli kod kojih je utvrđena prisutnost alela C polimorfizma -634 C/G živjeli duže (p=0.01), dok kod polimorfizma +936 C/T gena VEGF nije bilo statistički značajne razlike.
Abstract (english)
Colon cancer arises from a stepwise accumulation of genetic and epigenetic changes in the number of oncogenes and tumor suppressor genes. Angiogenesis is necessary for the formation and progression of tumors, and vascular endothelial growth factor (VEGF) is one of its key mediators. Since the VEGF expression can be affected by regulatory SNP polymorphisms, objective of this study was to investigate the role of these polymorphisms in the susceptibility to and survival of patients with sporadic colorectal cancer. VEGF polymorphisms -634G/C and +936 C/T were genotyped using TaqManTM real-time PCR. No association was found between genotypes and haplotypes and susceptibility to sporadic colorectal cancer. Survival analysis showed that patients with established presence of VEGF -634 C allele lived longer (p=0.01), while the +936 C/T VEGF polymorphism had no influence on patients’ survival.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:936430
Study programmeTitle: Molecular Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra molekularne biologije (magistar/magistra molekularne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-27 12:36:45