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master's thesis
Poboljšanje topljivosti nabumetona uslijed kompleksiranja s odabranim ciklodekstrinima
Zagreb: University of Zagreb, Faculty of Science, 2021. urn:nbn:hr:217:227666
Jukić, Nino
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Jukić, N. (2021). Poboljšanje topljivosti nabumetona uslijed kompleksiranja s odabranim ciklodekstrinima (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:227666

Jukić, Nino. "Poboljšanje topljivosti nabumetona uslijed kompleksiranja s odabranim ciklodekstrinima." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:227666

Jukić, Nino. "Poboljšanje topljivosti nabumetona uslijed kompleksiranja s odabranim ciklodekstrinima." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:227666

Jukić, N. (2021). 'Poboljšanje topljivosti nabumetona uslijed kompleksiranja s odabranim ciklodekstrinima', Master's thesis, University of Zagreb, Faculty of Science, accessed 23 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:227666

Jukić N. Poboljšanje topljivosti nabumetona uslijed kompleksiranja s odabranim ciklodekstrinima [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2021 [cited 2024 December 23] Available at: https://urn.nsk.hr/urn:nbn:hr:217:227666

N. Jukić, "Poboljšanje topljivosti nabumetona uslijed kompleksiranja s odabranim ciklodekstrinima", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:217:227666

Metadata
TitlePoboljšanje topljivosti nabumetona uslijed kompleksiranja s odabranim ciklodekstrinima
Title (english)Enhancement of nabumetone solubility by complexation with selected cyclodextrins
AuthorNino Jukić
MentorNives Galić (mentor)
Committee memberNives Galić (predsjednik povjerenstva)
Committee memberŽeljka Soldin (član povjerenstva)
Committee memberĐani Škalamera (član povjerenstva)
Committee memberAdriana Kenđel (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2021-02-01, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Nabumeton je nesteroidni protuupalni predlijek koji se u jetri metabolizira u svoj farmakološki aktivan oblik, 6-metoksi-2-naftiloctenu kiselinu koja djeluje kao inhibitor enzima ciklooksigenaza. Prema biofarmaceutskom sustavu klasifikacije djelatnih tvari nabumeton spada u lijekove skupine II (slaba topljivost, dobra permeabilnost). Utvrđeno je da se topljivost nabumetona u vodi i u biorelevantnim medijima povećava ukoliko je kompleksiran s ciklodekstrinom. U sklopu ovog diplomskog rada istražen je utjecaj β- ciklodekstrina i njegovog alkilsulfoniranog derivata, sulfobutileter-β-ciklodekstrina na topljivost nabumetona u vodi i u biorelevantnim medijima. Kvantitativno određivanje nabumetona provedeno je UV/Vis apsorpcijskom spektroskopijom i fluorescencijskom spektroskopijom uz pomoć prethodno razvijenih i validiranih metoda. Pripravljeni su uzorci nabumetona i navedenih ciklodekstrina u čvrstom stanju mljevenjem u visokoenergijskim vibracijskim mlinovima te su okarakterizirani primjenom infracrvene spektroskopije s Fourierovom transformacijom te tehnike prigušene totalne refleksije. Uzorcima pripravljenim u čvrstom stanju ispitana je topljivost te je uspoređena s intrinzičnom topljivošću nabumetona u vodi.
Abstract (english)
Nabumetone is a nonsteroidal anti-inflammatory prodrug which is metabolized in the liver to its pharmacological active metabolite, 6-methoxy-2-naphthylacetic acid which acts as cyclooxygenase inhibitor. According to the Biopharmaceutical Classification System nabumetone is categorized as class II compound (low solubility, high permeability). Studies have shown that solubility of nabumetone in water and biorelevant media increases if complexed with cyclodextrin. Effect of β-cyclodextrin and its alkyl sulfonated derivative sulfobutylether-β-cyclodextrine on solubility of nabumetone in water and biorelevant media was studied in this thesis. Nabumetone was quantitatively determined by developed and validated UV/Vis spectrophotometric and spectrofluorimetric methods. Samples of nabumetone and mentioned cyclodextrins in the solid state were prepared in high-energy vibrational mills and were characterized by Fourier-transform infrared spectroscopy and attenuated total reflectance. Samples prepared in the solid state were analyzed and compared with intrinsic solubility of nabumetone in water as well.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:227666
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-02-01
Terms of useLicence In copyright icon
Created on2021-03-08 12:49:53