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master's thesis
Polimorfizmi gena serotoninskog receptora 2A i agresivno ponašanje u adolescenata s poremećajem ophođenja
Zagreb: University of Zagreb, Faculty of Science, 2021. urn:nbn:hr:217:894394
Kerum, Antonia
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Kerum, A. (2021). Polimorfizmi gena serotoninskog receptora 2A i agresivno ponašanje u adolescenata s poremećajem ophođenja (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:894394

Kerum, Antonia. "Polimorfizmi gena serotoninskog receptora 2A i agresivno ponašanje u adolescenata s poremećajem ophođenja." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:894394

Kerum, Antonia. "Polimorfizmi gena serotoninskog receptora 2A i agresivno ponašanje u adolescenata s poremećajem ophođenja." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:894394

Kerum, A. (2021). 'Polimorfizmi gena serotoninskog receptora 2A i agresivno ponašanje u adolescenata s poremećajem ophođenja', Master's thesis, University of Zagreb, Faculty of Science, accessed 28 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:894394

Kerum A. Polimorfizmi gena serotoninskog receptora 2A i agresivno ponašanje u adolescenata s poremećajem ophođenja [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2021 [cited 2024 November 28] Available at: https://urn.nsk.hr/urn:nbn:hr:217:894394

A. Kerum, "Polimorfizmi gena serotoninskog receptora 2A i agresivno ponašanje u adolescenata s poremećajem ophođenja", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:217:894394

Metadata
TitlePolimorfizmi gena serotoninskog receptora 2A i agresivno ponašanje u adolescenata s poremećajem ophođenja
Title (english)Serotonin receptor 2A gene polymorphisms and aggressive behavior in adolescents with behavioral disorders
AuthorAntonia Kerum
MentorGordana Nedić Erjavec (mentor)
MentorDubravka Hranilović (sumentor)
Committee memberDubravka Hranilović (predsjednik povjerenstva)
Committee memberAntun Alegro (član povjerenstva)
Committee memberJasna Lajtner (član povjerenstva)
Committee memberMaja Matulić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2021-02-26, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Agresivno ponašanje je uočljiva manifestacija agresije te se definira kao bilo koji čin s ciljem izazivanja štete, boli ili ozljede. Agresija se povezuje s poremećajima u kortikolimbičkoj mreži, a na razini neurotransmitera, povezuje se s promjenama u serotoninskom sustavu. Prijašnje studije upućuju na povezanost pojedinih polimorfizama gena serotoninskog receptora 2A (HTR2A) s agresivno-impulzivnim osobinama ili adolescentskim antisocijalnim ponašanjem. Cilj ovog rada bio je ispitati povezanost genotipova s obzirom na polimorfizme rs2070040 i rs9534511 gena HTR2A i težine agresivnog ponašanja kod adolescenata s poremećajem ophođenja i parcijalnim sindromom kod kojih su za procjenu agresivnog ponašanja korištene samoocjenska ljestvica za procjenu agresivnosti AG-87 i ljestvica otvorene agresivnosti-modificirana verzija (OAS-M). Studija je uključila 227 adolescenata muškog spola podijeljenih u 4 skupine, ispitanici s težim i ispitanici s lakšim poremećajem ophođenja, ispitanici s parcijalnim sindromom te zdravi kontrolni ispitanici. Na temelju dobivenih rezultata, nameće se zaključak da ne postoji povezanost polimorfizama rs2070040 i rs9534511 gena HTR2A i agresivnog ponašanja u muških adolescenata s poremećajem ophođenja. Evidentan je samo blagi utjecaj genotipa s obzirom na polimorfizam rs2070040 gena HTR2A na ukupan broj bodova ostvarenih na ljestvici OAS-M. (59 stranica, 11 slika, 16 tablica, 118 literaturnih
Abstract (english)
Aggressive behavior is a visible manifestation of aggression and it is defined as any act aimed at causing harm, pain or injury. Aggression is associated with disturbances in the corticolimbic network, and at the neurotransmitter level, it is associated with changes in the serotonergic system. Previous studies suggest the association of different serotonin receptor 2A (HTR2A) gene polymorphisms with aggressive-impulsive traits or antisocial behavior in adolescence. The aim of this study was to examine the association of genotypes according to polymorphisms rs2070040 and rs9534511 of the HTR2A gene and severity of aggressive behavior in adolescents with behavioral disorders and partial syndrome in whome the aggressive behavior was evaluated by selfadministred aggression scale AG-87 and the overt aggression scale modified (OAS-M) version. The study included 227 male adolescents divided into 4 groups, subjects with severe and subjects mild conduct disorder, subjects with partial syndrome and healthy control subjects. Based on the obtained results, it is concluded that there is no association between rs2070040 and rs9534511 polymorphisms of the HTR2A gene and aggressive behavior in male adolescents with conduct disorder. Only a slight influence of genotype with respect to the rs2070040 polymorphism of the HTR2A gene on the total OAS-M score is evident.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:894394
Study programmeTitle: Experimental Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-03-09 08:17:13