prikaz prve stranice dokumenta Uloga krizina na histomorfometrijske značajke osteoporoze prouzročene retinoičnom kiselinom u štakora
Access restricted to students and staff of home institution
master's thesis
Uloga krizina na histomorfometrijske značajke osteoporoze prouzročene retinoičnom kiselinom u štakora
Zagreb: University of Zagreb, Faculty of Science, 2013. urn:nbn:hr:217:657670
Sašilo, Kristijan
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

Cite this document

Sašilo, K. (2013). Uloga krizina na histomorfometrijske značajke osteoporoze prouzročene retinoičnom kiselinom u štakora (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:657670

Sašilo, Kristijan. "Uloga krizina na histomorfometrijske značajke osteoporoze prouzročene retinoičnom kiselinom u štakora." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:657670

Sašilo, Kristijan. "Uloga krizina na histomorfometrijske značajke osteoporoze prouzročene retinoičnom kiselinom u štakora." Master's thesis, University of Zagreb, Faculty of Science, 2013. https://urn.nsk.hr/urn:nbn:hr:217:657670

Sašilo, K. (2013). 'Uloga krizina na histomorfometrijske značajke osteoporoze prouzročene retinoičnom kiselinom u štakora', Master's thesis, University of Zagreb, Faculty of Science, accessed 27 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:657670

Sašilo K. Uloga krizina na histomorfometrijske značajke osteoporoze prouzročene retinoičnom kiselinom u štakora [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2013 [cited 2024 December 27] Available at: https://urn.nsk.hr/urn:nbn:hr:217:657670

K. Sašilo, "Uloga krizina na histomorfometrijske značajke osteoporoze prouzročene retinoičnom kiselinom u štakora", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2013. Available at: https://urn.nsk.hr/urn:nbn:hr:217:657670

Metadata
TitleUloga krizina na histomorfometrijske značajke osteoporoze prouzročene retinoičnom kiselinom u štakora
Title (english)The role of chrysin on the histomorphometrical characteristics of osteoporosis caused by retinoic acid in rats
AuthorKristijan Sašilo
MentorNada Oršolić (mentor)
Committee memberNada Oršolić (predsjednik povjerenstva)
Committee memberBožena Mitić (član povjerenstva)
Committee memberMirjana Kalafatić (član povjerenstva)
Committee memberVesna Benković (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2013-09-25, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Oksidativni stres nastaje uslijed neravnoteže između povećane proizvodnje reaktivnih kisikovih radikala i nedovoljne aktivnosti antioksidativnih sustava. Uloga radikala utvrđena je u patogenezi brojnih bolesti, uključujući i osteoporozu. Lipidna peroksidacija jedna je od glavnih karakteristika oksidativnog stresa, a malondialdehid (MDA) jedan je od njenih krajnjih proizvoda te mjera proizvodnje slobodnih radikala. Pokazano je da med (pčelinji proizvod bogat antioksidansom krizinom) ima značajan učinak u sprječavanju osteoporoze stoga smo istražili učinak krizina na težinu, histomorfometrijske parametre kostiju, udio kalcija i fosfora te koncentracije MDA i glutationa (GSH) pokusnih životinja. Na temelju rezultata zaključili smo da krizin ima značajnu antioksidativnu i antiosteoporotsku aktivnost te da bi njegova primjena mogla poslužiti u sprječavanju osteoporoze i razumijevanju odnosa između funkcionalne prehrane i zdravlja.
Abstract (english)
Disbalance between the increased production of reactive oxygen species and the inadequate activity of the antioxidant system causes oxidative stress. Role of the free radical in pathogenesis of many diseases, including osteoporosis, has been confirmed. Lipid peroxidation is one of the main characteristics of the oxidative stress, and malondialdehyde (MDA) one of its ultimate products, as well as the indicator of free radical production. It has been shown that bee honey (a natural product rich in antioxidant chrysin) has significant effect on prevention of osteoporosis, therefore we decided to investigate the effects of chrysin on body weight, histomorphometrical parameters of bone, calcium and phosphorus contents, as well as on concentrations of MDA and glutathione (GSH) in test animals. Based on the obtained results, we concluded that chrysin displays significant antioxidative and antiosteoporotic activity and that its use could be helpful in preventing osteoporosis and understanding the relationship between the functional diet and health.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:657670
Study programmeTitle: Experimental Biology
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra eksperimentalne biologije (magistar/magistra eksperimentalne biologije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2017-04-28 08:07:09