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doctoral thesis
Stereokemija kompleksa 2,2'-iminoacetamida i bis(piridin-2-ilmetil)amina te njihova primjena u enantioselektivnoj katalizi
Zagreb: University of Zagreb, Faculty of Science, 2021. urn:nbn:hr:217:577369
Pantalon Juraj, Natalija
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Pantalon Juraj, N. (2021). Stereokemija kompleksa 2,2'-iminoacetamida i bis(piridin-2-ilmetil)amina te njihova primjena u enantioselektivnoj katalizi (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:577369

Pantalon Juraj, Natalija. "Stereokemija kompleksa 2,2'-iminoacetamida i bis(piridin-2-ilmetil)amina te njihova primjena u enantioselektivnoj katalizi." Doctoral thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:577369

Pantalon Juraj, Natalija. "Stereokemija kompleksa 2,2'-iminoacetamida i bis(piridin-2-ilmetil)amina te njihova primjena u enantioselektivnoj katalizi." Doctoral thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:577369

Pantalon Juraj, N. (2021). 'Stereokemija kompleksa 2,2'-iminoacetamida i bis(piridin-2-ilmetil)amina te njihova primjena u enantioselektivnoj katalizi', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:577369

Pantalon Juraj N. Stereokemija kompleksa 2,2'-iminoacetamida i bis(piridin-2-ilmetil)amina te njihova primjena u enantioselektivnoj katalizi [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2021 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:217:577369

N. Pantalon Juraj, "Stereokemija kompleksa 2,2'-iminoacetamida i bis(piridin-2-ilmetil)amina te njihova primjena u enantioselektivnoj katalizi", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:217:577369

Metadata
TitleStereokemija kompleksa 2,2'-iminoacetamida i bis(piridin-2-ilmetil)amina te njihova primjena u enantioselektivnoj katalizi
Title (english)Stereochemistry of 2,2'-iminodiacetamide and bis(2-pyridine-2-ylmethyl)amine complexes and their application in enantioselective catalysis
AuthorNatalija Pantalon Juraj
MentorSrećko Kirin (mentor)
Committee memberVišnja Vrdoljak (predsjednik povjerenstva)
Committee memberKrunoslav Užarević (član povjerenstva)
Committee memberIvanka Jerić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2021-07-07, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Universal decimal classification
(UDC)		54 - Chemistry. Crystallography. Mineralogy
Abstract
.U okviru ove disertacije proučavana je stereokemija kompleksa 2,2'-iminodiacetamida i bis(piridin-2-ilmetil)amina, te je ispitan utjecaj supstituenata na ligandu, aniona, i nekovalentnih interakcija. Pripravljeni ligandi podijeljeni su u četiri skupine. Priređeno je 8 različito supstituiranih iminodiacetamidnih liganada (A) te je istražen utjecaj supstituenata na stereokemiju metalnih kompleksa. S H-supstituiranim ligandom dobivena je kristalna struktura cis-fac kompleksa, dok su s ostalim ligandima dobiveni trans-fac izomeri. S izopropil-supstituiranim bis(piridin-2-ilmetil)aminskim ligandom (B) priređeni su kompleksi koristeći Cu(II) i Zn(II) s različitim anionima. Ovisno o anionu, dobivene su kristalne strukture monomera, dimera, cis-fac-ML2 kompleksa te ciklički trimer koji veže CO2 iz zraka. Kompleksi Fe(II) s 2 cikloheksandiaminska derivata (C) ispitani su u katalitičkim reakcijama kao mimici enzima flavon sintaze. Također je priređeno 7 bis(piridin-2-ilmetil)aminskih i 5 iminodiacetamidnih liganada (D) s različitom duljinom CH2 poveznice i različitim kiralnim skupinama kako bi se istražio utjecaj strukturnih promjena na koordinacijska svojstva liganada u kompleksima Cu(II) i Zn(II). Ligandi s 3 CH2 skupine tvorili su komplekse ML2 stehiometrije, dok je kod liganada s 2 CH2 skupine došlo do koordinacije pokrajnjeg lanca i stvaranja ML kompleksa. Kompleksi ML stehiometrije pokazali su aktivnost u DNA cijepanju.
Abstract (english)
In this dissertation, the stereochemistry of 2,2'-iminodiacetamide and bis(pyridin-2-ylmethyl) amine ligand complexes was studied, focusing on the influence of substituents on the ligand, anion and noncovalent interactions. The prepared ligands were divided into four groups. Eight differently substituted iminodiacetamide ligands (A) were prepared. A cis-fac crystal structure was obtained with the H-substituted ligand, while the other ligands gave trans-fac isomers. Complexes with Cu(II) and Zn(II) were prepared with a isopropyl-substituted bis(2-pyridine-2-ylmethyl)amine ligand (B). Depending on the anion, crystal structures of monomers, dimers, a cis-fac-ML2 complex and a cyclic trimer that binds CO2 from air were obtained. Fe(II) complexes with two cyclohexanediamine derivatives (C) were investigated in catalytic reactions as flavone synthase mimics. Furthermore, 7 bis(2-pyridine-2-ylmethyl)amine and 5 iminodiacetamide ligands (D) with different lengths of CH2 linkers and different chiral groups were prepared to study the influence of structural changes on the coordination properties of these ligands in Cu(II) and Zn(II) complexes. Ligands with 3 CH2 groups formed ML2 complexes, while ligands with 2 CH2 groups showed side chain coordination and formation of ML complexes. Complexes of ML stoichiometry showed DNA cleavage activity
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:577369
Promotion2021
Study programmeTitle: Doctoral study in chemistry
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija (doktor/doktorica znanosti, područje prirodnih znanosti, polje kemija)
Type of resourceText
Extent147 str. ; 30 cm
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-07-07
Terms of useLicence In copyright icon
Created on2021-07-13 12:18:04