We have investigated the effect of rhyhmic tonal stimulation on changes of body weight and observed hematological parameters of BALB/c mice intoxicated with hematotoxic poison lindan. Based on the type of treatment four groups of animals were formed: Control, Poison, Sound and Sound+poison. Mice in groups Sound and Sound+poison during the experimental period from 7p.m. - 7a.m. were exposed to rhythmic tonal stimulation of 152 beats per minute with standardized frequency of 440 Hz. Mice in groups Poison and Sound+Poison have been treated with subletal dose (LD50) of lindan during the period of 30 days receiving 1/10 of dose every 3 days. Lindan was proven to be significantly negative stressor, as in the males it has influenced the statistically significant body weight loss (p=0.0378*, p<0,05). Significant differences between sexes regarding the intluence of the rhythmic tonal stimulation have been observed. Impact of the Sound treatment on the observed parameters pertaining to immune system expresses in males as somewhat positive stressor, while in females it has the effect of negative stressor, although statistically insignificant. In males Sound treatment acts as a strong positive stressor on increase of the body weight with statistical significance (p=0,0404*, p<0,05). Combined treatment Sound+Poison in males shows the statistical significanse of the increase in body weight (p=0,0023**, p<0,01), number of leukocytes (p=0,0031**, p<0,01) and lymphocytes (p=0,0070**, p<0,01) comparing to the treatment with lindan only. That indicates the positive effects of rhytmic tonal stimulation on immuno-hematopoesis in speeding up the process of recovery of the disrupted immune system in males. Generally, it may be concluded that males of the BAIB/c mice are more sensitive then females on influence of both positive and negative stressors.