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master's thesis
Analiza inkluzijskih kompleksa loratadina i ciklodekstrina spektrometrijom masa visokog razlučivanja
Zagreb: University of Zagreb, Faculty of Science, 2021. urn:nbn:hr:217:159242
Živko, Ana-Emina
University of Zagreb
Faculty of Science
Department of Chemistry

Institutional repository: Repository of the Faculty of Science

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Živko, A. E. (2021). Analiza inkluzijskih kompleksa loratadina i ciklodekstrina spektrometrijom masa visokog razlučivanja (Master's thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:159242

Živko, Ana Emina. "Analiza inkluzijskih kompleksa loratadina i ciklodekstrina spektrometrijom masa visokog razlučivanja." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:159242

Živko, Ana Emina. "Analiza inkluzijskih kompleksa loratadina i ciklodekstrina spektrometrijom masa visokog razlučivanja." Master's thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:159242

Živko, A. E. (2021). 'Analiza inkluzijskih kompleksa loratadina i ciklodekstrina spektrometrijom masa visokog razlučivanja', Master's thesis, University of Zagreb, Faculty of Science, accessed 21 December 2024, https://urn.nsk.hr/urn:nbn:hr:217:159242

Živko AE. Analiza inkluzijskih kompleksa loratadina i ciklodekstrina spektrometrijom masa visokog razlučivanja [Master's thesis]. Zagreb: University of Zagreb, Faculty of Science; 2021 [cited 2024 December 21] Available at: https://urn.nsk.hr/urn:nbn:hr:217:159242

A. E. Živko, "Analiza inkluzijskih kompleksa loratadina i ciklodekstrina spektrometrijom masa visokog razlučivanja", Master's thesis, University of Zagreb, Faculty of Science, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:217:159242

Metadata
TitleAnaliza inkluzijskih kompleksa loratadina i ciklodekstrina spektrometrijom masa visokog razlučivanja
Title (english)High resolution mass spectrometric analysis of loratadine- cyclodextrine inclusion complexes
AuthorAna-Emina Živko
MentorNives Galić (mentor)
Committee memberNives Galić (predsjednik povjerenstva)
Committee memberŽeljka Soldin (član povjerenstva)
Committee memberJasmina Rokov Plavec (član povjerenstva)
Committee memberIva Juranović Cindrić (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Chemistry)
Zagreb
Defense date and country2021-09-13, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Inkluzijski kompleksi, nastali uslijed nekovalentnih interakcija između molekule domaćina i molekule gosta, rješenje su problema slabo topljivih lijekova. Kompleksiranje lijeka, zarobljenog u hidrofobnoj šupljini molekule domaćina, poboljšava njegova fizikalno-kemijska svojstva poput topljivosti i biodostupnosti. β-ciklodekstrin i njegov nasumično metilirani derivat izabrani su kao molekule domaćini, dok je molekula gost loratadin, lijek korišten u liječenju alergijskih poremećaja. Nastali inkluzijski kompleksi, također i spojevi koji ih grade, analizirani su hibridnim spektrometrom masa s kvadrupolom i analizatorom vremena leta. Tandemna spektrometrija masa provedena je nad izabranim ionima te je na temelju dobivenih rezultata predložen fragmentacijski put analiziranih spojeva. Korištena ionizacijska tehnika je elektroraspršenje, a spektri masa snimljeni su u pozitivnom i negativnom načinu snimanja.
Abstract (english)
Inclusion complexes, formed by noncovalent interactions between host molecule and guest molecule, are the solution of the problem of poorly soluble drugs. Encapsulation of the drugs in the hidrophobic cavity of the host molecule improves its physico-chemical properties, such as solubility and bioavailability. β-cyclodextrin and its randomly methylated derivative were selected as host molecules, while the guest molecule was the drug loratadine, used in the treatment of allergic disorders. Inclusion complexes, as well as the coumpounds that form them, were analyzed by a hibrid mass spectrometer with a quadrupole and a time-of-flight analyzer. Tandem mass spectrometry was performed on the selected ions and the fragmentation pathway of the analyzed compounds was proposed based on the obtained results. Electrospray was used as the ionization technique, and the mass spectra were recorded in positive and negative mode.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:159242
Study programmeTitle: Graduate university studies in chemistry; specializations in: Research programme
Course: Research programme
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-09-13
Terms of useLicence In copyright icon
Created on2021-09-15 07:48:13