prikaz prve stranice dokumenta Funkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina
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doctoral thesis
Funkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina
Zagreb: University of Zagreb, Faculty of Science, 2021. urn:nbn:hr:217:800927
Baković, Petra
University of Zagreb
Faculty of Science
Department of Biology

Institutional repository: Repository of the Faculty of Science

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Baković, P. (2021). Funkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina (Doctoral thesis). Zagreb: University of Zagreb, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:217:800927

Baković, Petra. "Funkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina." Doctoral thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:800927

Baković, Petra. "Funkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina." Doctoral thesis, University of Zagreb, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:217:800927

Baković, P. (2021). 'Funkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina', Doctoral thesis, University of Zagreb, Faculty of Science, accessed 25 November 2024, https://urn.nsk.hr/urn:nbn:hr:217:800927

Baković P. Funkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina [Doctoral thesis]. Zagreb: University of Zagreb, Faculty of Science; 2021 [cited 2024 November 25] Available at: https://urn.nsk.hr/urn:nbn:hr:217:800927

P. Baković, "Funkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina", Doctoral thesis, University of Zagreb, Faculty of Science, Zagreb, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:217:800927

Metadata
TitleFunkcionalni i molekularni učinci prehrane bogate mastima u štakora s promijenjenom homeostazom serotonina
Title (english)Functional and molecular effects of high-fat diet: studies in sublines of rats with constitutionally altered serotonin homeostasis
AuthorPetra Baković
MentorJasminka Štefulj (mentor)
Committee memberSofia Ana Blažević (predsjednik povjerenstva)
Committee memberLipa Čičin-Šain (član povjerenstva)
Committee memberMaja Jazvinšćak Jembrek (član povjerenstva)
GranterUniversity of Zagreb
Faculty of Science
(Department of Biology)
Zagreb
Defense date and country2021, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Održavanje energetske ravnoteže je složena fiziološka funkcija čija disregulacija može rezultirati pretilošću i metaboličkim poremećajima poput dijabetesa. Ovim radom željelo se doprinijeti boljem razumijevanju uloge serotonina (5HT) u mehanizmima regulacije energetske homeostaze, korištenjem sublinija štakora s konstitucijski povišenom (5HT-visoka) ili sniženom (5HT-niska) aktivnošću serotonina. Životinje iz obiju sublinija podvrgnute su visokokaloričnoj prehrani s visokim udjelom masti te je uspoređen njihov funkcionalni i molekularni odgovor na takav metabolički izazov. U skladu s prethodnim nalazima, životinje iz 5HT-visoke sublinije su u uvjetima standardne prehrane imale lošije metaboličko zdravlje od 5HT-niskih životinja. Međutim, 5HT-niske životinje su u odgovoru na visokokaloričnu prehranu pokazale veću sklonost debljanju, slabiju regulaciju glikemije, jači razvoj rezistencije na inzulin te veće promjene u ekspresiji različitih gena u hipotalamusu i bijelom masnom tkivu. Dobiveni rezultati pokazuju da je konstitucijski snižena aktivnost serotonina povezana s većom osjetljivošću na štetne učinke visokokalorične prehrane.
Abstract (english)
Maintenance of energy balance is a complex physiological function, dysregulation of which can lead to obesity and metabolic disorders such as diabetes. Here, we aimed to contribute to a better understanding of the role of serotonin (5HT) in the mechanisms regulating energy homeostasis, by using sublines of rats with constitutionally increased (5HT-high) or decreased (5HT-low) activity of 5HT. Animals from both sublines were subjected to a high-calorie, high-fat diet and compared for their functional and molecular response to this metabolic challenge. Consistent with previous findings, when administered conventional diet, animals from the 5HT-high subline had poorer metabolic health than animals from 5HT-low subline. However, in response to a high-fat diet, 5HT-low animals showed a greater tendency to gain weight, poorer glycemic control, higher development of insulin resistance, and more pronounced changes in the expression of various metabolic genes in the hypothalamus and adipose tissue. The obtained results suggest that constitutionally decreased activity of 5HT is associated with a higher susceptibility to adverse effects of a high-calorie diet.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:217:800927
Promotion2021
Study programmeTitle: Biology
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Embargo expiration date: 2023-07-23
Terms of useLicence In copyright icon
Created on2021-09-16 11:17:31