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undergraduate thesis
Melitin, peptid iz pčelinjeg otrova s antimikrobnim i antitumorskim djelovanjem
Split: University of Split, University of Split, Faculty of science, 2021. urn:nbn:hr:166:085722
Marcelić, Lucija
University of Split
Faculty of Science
Department of Biology

Institutional repository: Repository of Faculty of Science

Cite this document

Marcelić, L. (2021). Melitin, peptid iz pčelinjeg otrova s antimikrobnim i antitumorskim djelovanjem (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:085722

Marcelić, Lucija. "Melitin, peptid iz pčelinjeg otrova s antimikrobnim i antitumorskim djelovanjem." Undergraduate thesis, University of Split, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:166:085722

Marcelić, Lucija. "Melitin, peptid iz pčelinjeg otrova s antimikrobnim i antitumorskim djelovanjem." Undergraduate thesis, University of Split, Faculty of Science, 2021. https://urn.nsk.hr/urn:nbn:hr:166:085722

Marcelić, L. (2021). 'Melitin, peptid iz pčelinjeg otrova s antimikrobnim i antitumorskim djelovanjem', Undergraduate thesis, University of Split, Faculty of Science, accessed 02 August 2024, https://urn.nsk.hr/urn:nbn:hr:166:085722

Marcelić L. Melitin, peptid iz pčelinjeg otrova s antimikrobnim i antitumorskim djelovanjem [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2021 [cited 2024 August 02] Available at: https://urn.nsk.hr/urn:nbn:hr:166:085722

L. Marcelić, "Melitin, peptid iz pčelinjeg otrova s antimikrobnim i antitumorskim djelovanjem", Undergraduate thesis, University of Split, Faculty of Science, Split, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:166:085722

Metadata
TitleMelitin, peptid iz pčelinjeg otrova s antimikrobnim i antitumorskim djelovanjem
Title (english)Melittin, bee-venom peptide with antimicrobial and anticancer properties
AuthorLucija Marcelić
MentorAna Maravić (mentor)
MentorTomislav Rončević (pomoć pri izradi, neposredni voditelj)
Committee memberAna Maravić (predsjednik povjerenstva)
Committee memberŽeljana Fredotović (član povjerenstva)
Committee memberTomislav Rončević (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Biology)
Split
Defense date and country2021-09-24, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Antimikrobni peptidi su oligopeptidi građeni od 8 do 50 aminokiselina koji imaju direktnu antimikrobnu aktivnost i/ili imunomodulatorna svojstva. U kontekstu rastuće antimikrobne rezistencije, zadnjih desetljeća se proučavaju kao potencijalna alternativa tzv. "klasičnim" antibioticima. Jedan od takvih peptida je i melitin, AMP izoliran iz pčelinjeg otrova koji u in vitro uvjetima ima potentnu antimikrobnu i antitumorsku aktivnost, te pokazuje i protuupalna svojstva. Usprkos brojnim istraživanjima, ovaj peptid se još nije našao u kliničkoj primjeni, poglavito zbog izražene citotoksičnosti. Danas se tome pokušava doskočiti ispitujući sinergijski učinak melitina s konvencionalnim antibioticima. S druge strane, razvojem nanotehnologije radi se na razvoju nanonosača koji bi omogućili ciljanu primjenu što bi zahtijevalo puno manje koncentracije aktivne tvari čime bi se moguće nuspojave svele na minimum.
Abstract (english)
Antimicrobial peptides are oligopeptides composed of 8 to 50 aminoacids that have direct antimicrobial activity and/or immunomodulatory properties. In the context of growing antimicrobial resistance, they have been extensively studied in recent decades as a potential alternative to the so-called "classic" antibiotics. One of such peptides is melitin, AMP isolated from bee-venom, which showed strong in vitro antimicrobial and antitumor activity and also shows anti-inflammatory properties. Despite numerous studies, this peptide is not in clinical use, mostly due to its pronounced cytotoxicity. Today, attempts are being made to address this issue by studying the synergistic effect of melitin with conventional antibiotics. On the other hand, current work in the field of nanotechnology enabled us to pursue the development of nanocarriers which can allow targeted application, thus requiring much lower concentrations of active substances and minimizing possible side effects.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:085722
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to authenticated users
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Created on2021-10-12 11:18:54