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undergraduate thesis
Biološka aktivnost kvarterne soli 3-aminokinuklidina
Split: University of Split, University of Split, Faculty of science, 2022. urn:nbn:hr:166:015985
Bilandžić, Katijana
University of Split
Faculty of Science
Department of Chemistry

Institutional repository: Repository of Faculty of Science

Cite this document

Bilandžić, K. (2022). Biološka aktivnost kvarterne soli 3-aminokinuklidina (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:015985

Bilandžić, Katijana. "Biološka aktivnost kvarterne soli 3-aminokinuklidina." Undergraduate thesis, University of Split, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:166:015985

Bilandžić, Katijana. "Biološka aktivnost kvarterne soli 3-aminokinuklidina." Undergraduate thesis, University of Split, Faculty of Science, 2022. https://urn.nsk.hr/urn:nbn:hr:166:015985

Bilandžić, K. (2022). 'Biološka aktivnost kvarterne soli 3-aminokinuklidina', Undergraduate thesis, University of Split, Faculty of Science, accessed 28 April 2024, https://urn.nsk.hr/urn:nbn:hr:166:015985

Bilandžić K. Biološka aktivnost kvarterne soli 3-aminokinuklidina [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2022 [cited 2024 April 28] Available at: https://urn.nsk.hr/urn:nbn:hr:166:015985

K. Bilandžić, "Biološka aktivnost kvarterne soli 3-aminokinuklidina", Undergraduate thesis, University of Split, Faculty of Science, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:166:015985

Metadata
TitleBiološka aktivnost kvarterne soli 3-aminokinuklidina
Title (english)Biological activity of 3-aminoquinuclidine quaternary salt
AuthorKatijana Bilandžić
MentorRenata Odžak (mentor)
MentorMatilda Šprung (mentor)
Committee memberRenata Odžak (predsjednik povjerenstva)
Committee memberBarbara Soldo (član povjerenstva)
Committee memberMatilda Šprung (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Chemistry)
Split
Defense date and country2022, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Kvarterni amonijevi spojevi (QACs) su amfifilni spojevi, izuzetnih svojstava i širokih mogućnosti primjene. Pokazuju vrlo dobru biološku aktivnost te zahvaljujući svojim antimikrobnim svojstvima veliki su potencijal u proizvodnji novih antibiotika. Zbog razvoja nepoželjne bakterijske rezistencije na ove spojeve, trenutno je u središtu pažnje sinteza modificiranih kvarternih amonijevih soli koje su razgradive, a u isto vrijeme jednako efikasne. U svrhu ovog istraživanja je novosintetiziranoj soli 3-aminokinuklidina s alifatskim lancem od 16 ugljikovih atoma metodom mikrodilucije određena biološka aktivnost na sedam bakterijskih sojeva: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Salmonella enteritidis, Listeria monocytogenes i Bacillus cereus. Dobivene vrijednosti minimalnih inhibitornih koncentracija potvrdile su prethodna istraživanja da QACs pokazuju široki raspon antimikrobne aktivnosti s boljim djelovanjem na Gram-pozitivne bakterije.
Abstract (english)
Quarternary ammonium compounds (QACs) are amphiphilic compounds of exceptional properties and a wide range of application possibilities. They display very good biological activity and owing to their antimicrobial properties, they exert great potential in the production of new antibiotics. Due to the development of bacterial resistance to QACs, the current aim is to synthesize new and modified QACs which are biodegradable, but still efficient. For this research purposes, the biological activity of newly synthesized 3-aminoquinuclidine quarternary salt, containing 16 carbon atoms in an alkyl chain, has been investigated by microdilution method on seven bacterial strains: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Salmonella enteritidis, Listeria monocytogenes and Bacillus cereus. Obtained minimum inhibitory concentrations have confirmed the previous findings that QACs exhibit wide-range antibacterial potential with better activity against Gram-positive bacteria.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:015985
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2022-12-19 13:20:32