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undergraduate thesis
Polimorfizam gena ACE kao genetska predispozicija razvoja bolesti koronarnih arterija
Split: University of Split, Faculty of Science, 2024. urn:nbn:hr:166:985135
Žilić, Petra
University of Split
Faculty of Science

Institutional repository: Repository of Faculty of Science

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Žilić, P. (2024). Polimorfizam gena ACE kao genetska predispozicija razvoja bolesti koronarnih arterija (Undergraduate thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:985135

Žilić, Petra. "Polimorfizam gena ACE kao genetska predispozicija razvoja bolesti koronarnih arterija." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:985135

Žilić, Petra. "Polimorfizam gena ACE kao genetska predispozicija razvoja bolesti koronarnih arterija." Undergraduate thesis, University of Split, Faculty of Science, 2024. https://urn.nsk.hr/urn:nbn:hr:166:985135

Žilić, P. (2024). 'Polimorfizam gena ACE kao genetska predispozicija razvoja bolesti koronarnih arterija', Undergraduate thesis, University of Split, Faculty of Science, accessed 17 February 2025, https://urn.nsk.hr/urn:nbn:hr:166:985135

Žilić P. Polimorfizam gena ACE kao genetska predispozicija razvoja bolesti koronarnih arterija [Undergraduate thesis]. Split: University of Split, Faculty of Science; 2024 [cited 2025 February 17] Available at: https://urn.nsk.hr/urn:nbn:hr:166:985135

P. Žilić, "Polimorfizam gena ACE kao genetska predispozicija razvoja bolesti koronarnih arterija", Undergraduate thesis, University of Split, Faculty of Science, Split, 2024. Available at: https://urn.nsk.hr/urn:nbn:hr:166:985135

Metadata
TitlePolimorfizam gena ACE kao genetska predispozicija razvoja bolesti koronarnih arterija
Title (english)ACE gene polymorphism as a genetic predisposition for the development of coronary artery disease
AuthorPetra Žilić
MentorJasna Puizina (mentor)
Committee memberJasna Puizina (predsjednik povjerenstva)
Committee memberMate Šantić (član povjerenstva)
Committee memberAntonela Sovulj (član povjerenstva)
GranterUniversity of Split
Faculty of Science
Split
Defense date and country2024-09-24, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Abstract
Koronarna arterijska bolest (CAD) predstavlja jedan od vodećih uzroka smrti u većini razvijenih zemalja. Glavni problem te bolesti je suženje ili blokada koronarnih arterija koje opskrbljuju srce krvlju, što dovodi do smanjenog protoka krvi i može izazvati srčani udar. Jedan od ključnih čimbenika uključenih u razvoj kardiovaskularnih bolesti je renin-angiotenzinski sustav (RAS). Unutar tog sustava, angiotenzin-konvertirajući enzim (ACE) ima ključnu ulogu, jer pretvara angiotenzin I u angiotenzin II. Polimorfizam gena ACE ima važan utjecaj na razine enzima ACE u tijelu. Postoje tri glavna genotipa - DD, ID, i II. Genotip DD povezan je s najvišim razinama proteina ACE u cirkulaciji, što može povećati rizik od razvoja kardiovaskularnih bolesti, dok genotip II pokazuje najniže razine proteina ACE, što može biti zaštitno u određenim situacijama.
Abstract (english)
Coronary artery disease (CAD) is one of the leading causes of death in most developed countries. The main problem of this disease is the narrowing or blockage of the coronary arteries that supply the heart with blood, which leads to reduced blood flow and can cause a heart attack. One of the key factors involved in the development of cardiovascular diseases is the renin- angiotensin system (RAS). Within this system, angiotensin-converting enzyme (ACE) plays a key role, as it converts angiotensin I to angiotensin II. The polymorphism of the ACE gene has an important influence on the levels of the ACE enzyme in the body. There are three main genotypes - DD, ID, and II. The DD genotype is associated with the highest levels of ACE in the circulation, which may increase the risk of developing cardiovascular disease, while the II genotype shows the lowest levels of ACE, which may be protective in certain situations.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:166:985135
Study programmeTitle: Biology and Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) biologije i kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-14 09:27:20