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doctoral thesis
Modifying the proteostasis status: the role of cross-organelle communication
Split: University of Split, Faculty of Science, 2020. urn:nbn:hr:166:030651
Kanunnikau, Matea
University of Split
Faculty of Science
Department of Physics

Institutional repository: Repository of Faculty of Science

Cite this document

Kanunnikau, M. (2020). Modifying the proteostasis status: the role of cross-organelle communication (Doctoral thesis). Split: University of Split, Faculty of Science. Retrieved from https://urn.nsk.hr/urn:nbn:hr:166:030651

Kanunnikau, Matea. "Modifying the proteostasis status: the role of cross-organelle communication." Doctoral thesis, University of Split, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:166:030651

Kanunnikau, Matea. "Modifying the proteostasis status: the role of cross-organelle communication." Doctoral thesis, University of Split, Faculty of Science, 2020. https://urn.nsk.hr/urn:nbn:hr:166:030651

Kanunnikau, M. (2020). 'Modifying the proteostasis status: the role of cross-organelle communication', Doctoral thesis, University of Split, Faculty of Science, accessed 28 March 2025, https://urn.nsk.hr/urn:nbn:hr:166:030651

Kanunnikau M. Modifying the proteostasis status: the role of cross-organelle communication [Doctoral thesis]. Split: University of Split, Faculty of Science; 2020 [cited 2025 March 28] Available at: https://urn.nsk.hr/urn:nbn:hr:166:030651

M. Kanunnikau, "Modifying the proteostasis status: the role of cross-organelle communication", Doctoral thesis, University of Split, Faculty of Science, Split, 2020. Available at: https://urn.nsk.hr/urn:nbn:hr:166:030651

Metadata
TitleModifying the proteostasis status: the role of cross-organelle communication
Title (croatian)Modifikacija statusa proteostaze: uloga komunikacije između staničnih organela
AuthorMatea Kanunnikau
MentorAnita Kriško (mentor)
Committee memberKatarina Vukojević (predsjednik povjerenstva)
Committee memberIrena Drmić-Hofman (član povjerenstva)
Committee memberBiljana Balen (član povjerenstva)
GranterUniversity of Split
Faculty of Science
(Department of Physics)
Split
Defense date and country2020-11-06, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Biology
Universal decimal classification
(UDC)		577 - Biochemistry. Molecular biology. Biophysics
Abstract
Perpetual exposure to fluctuating intrinsic and environmental conditions constitute a challenge for maintaining a stable proteome, and this predicament is surmounted by an intricate system of precisely controlled mechanisms that constitute proteostasis. Proteostasis, or protein homeostasis, is orchestrated by an elaborate interlock of signaling pathways collectively known as the proteostasis network, with molecular chaperones constituting its most prominent component. The compartmentalized... More eukaryotic cell has ascertained organelle-specific chaperones to surmount challenges to proteostasis, and this idiosyncrasy was resolved to be used to study cell-wide effect upon proteostasis modifications in distinct cellular compartments. This study revealed an elaborate cross-organelle communication networking system upon compartmentalized improvement of proteostasis, induced by chaperone enrichment, as well as mild deterioration of proteostasis, induced by chaperone deletions. Comprehensive and detailed experiments confirmed that the improvement of proteostasis, as well as its mild deterioration initiates a cell-wide response which, ultimately, entails replicative lifespan extension, irrespective of the origin of alteration. This research postulates that this cell-wide response is orchestrated by sensing and mediating the protein folding quality status of the proteome in distinct cellular compartments, a response termed here cross-organelle stress response (CORE). Less
Abstract (croatian)
Kontinuirana izloženost oscilirajućim uvjetima, unutarnjim i vanjskim, predstavljaju izazov za očuvanjem uravnoteženog proteoma što regulirano proteostatskom mrežom. Najistaknutiji segment navedene mreže su molekularni šaperoni koji uslijed svoje dinamičnosti i raznolikosti omogućavaju stabilizaciju proteina. Separacijom stanice u zasebne odjeljke stečeni su pripadajući šaperoni karakteristični za svaki organel. Kompartmentalizacijom eukariotske stanice je omogućeno uspostavljanje te... More očuvanje proteostaze u izdvojenim odjeljcima. Ova činjenica je bila poticaj za proučavanje utjecaja poboljšanja i pogoršanja proteostaze u izdvojenim staničnim odjeljcima na stanicu. Obuhvatnim i detaljnim eksperimentima je pokazano da modifikacija proteostaze, bilo delecijom ili overekspresijom pojedinih šaperona, kulminira produljenjem replikativnog životnog vijeka, neovisno o ishodištu same modifikacije. Pretpostavka ovog istraživanja je da je ovaj cijelo-stanični odaziv proveden kroz raspoznavanje i korespondenciju konformacijske vrsnoće proteoma u zasebnim staničnim odjeljcima, odaziv formuliran u ovoj studiji kao odaziv na stres kroz organele (CORE). Less
Keywords
Keywords (croatian)
Languageenglish
URN:NBNurn:nbn:hr:166:030651
Study programmeTitle: Postgraduate University Study of Biophysics
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija (doktor/doktorica znanosti, područje prirodnih znanosti, polje biologija)
Type of resourceText
Extent149 str. ; 30 cm
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2020-12-17 09:51:39
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