People with disabilities make up the world's largest minority with a share of 10% in the general population. People with disabilities are included in the group of persons with impaired employability. Such a poor position of people with disabilities in the world of employment leads to objective existential problems such as lower incomes, fewer opportunities for education, employment and the like. Accordingly, one of the priority policy areas of the Member States of the European Union is the employment of persons with disabilities, as it achieves full inclusion in the community of persons with disabilities themselves. Employment, guidance and education are key factors in the social inclusion and economic independence of persons with disabilities. People with disabilities may be employed in the open labor market or under special conditions, with the obligation to ensure reasonable adjustment of the workplace by the employer. Special forms of employment in the open labor market are supported employment and self-employment. Forms of protective employment are protective and integrative workshops. However, barriers that impede the participation of people with disabilities in the labor market are numerous, complex and rarely linked to one area of life. The aim of this paper is to outline the challenges faced by persons with disabilities in employment, to describe employment models in the Republic of Croatia and to compare them with EU countries in order to obtain some useful recommendations on how to improve the employment of persons with disabilities in the Republic of Croatia.