The research highlights the crucial role of adaptability, inclusivity, and collaboration in substance abuse prevention programs among adolescents. Key conclusions emphasize the need to tailor efforts to diverse youth groups and employ innovative approaches such as online resources and emotional intelligence programs. Recognizing the impact of the digital age underscores the need for digital tools to promote responsible behavior among youth on the internet. Collaboration with the justice system, schools, healthcare institutions, and other stakeholders is crucial for a comprehensive prevention system. Financial challenges and monitoring long-term effectiveness underscore the need for diverse funding sources and rigorous evaluation methods that include the targeted population. Partnerships with public health institutions, social services, schools, and media outlets reflect a holistic approach, addressing not only substance abuse but also strengthening social, emotional, and family resources. Organizations highlight the importance of involving youth in program development, adapting approaches, and continuously adjusting to societal changes, all grounded in evidence-based practices. Successful prevention of adolescent addiction requires a holistic, adaptable, and collaborative approach. Research results provide insights into evidence-based strategies, multidisciplinary approaches, and ongoing program adjustments. The focus is not only on suppressing substance consumption but also on creating a supportive environment that enhances youth resilience. Continuous research, evaluation, and innovation are crucial for organizations to enhance their programs and contribute to the long-term reduction of adolescent addiction