Abstract | Danas ljudi sve više konzumiraju hranu računajući i na njene sastojke koji se nalaze u
malim količinama, a koji mogu imati povoljan utjecaj na zdravlje. Takve sastojke nazivamo
biološki aktivne komponente hrane. Kvaliteta ovih supstanci ne mjeri se njihovom
količinskom zastupljenosti, nego razinom sposobnosti da tokom svoje biološke aktivnosti
mogu neutralizirati utjecaje štetnih tvari u ljudskom organizmu. Sve biološki aktivne
komponente se međusobno razlikuju kako po kemijskoj strukturi tako i po funkciji u
organizmu. U neke od ovih sastojaka ubrajaju se vitamini i minerali, karotenoidi, fenolni
spojevi, flavonoidi, fitosteroli, izoflavoni, enzimi, tanini, glikozidi, alkaloidi, i druge.
Glukozinolati pripadaju takvim tvarima koje su intenzivno istraživane na području
prehrane i medicine, te se smatra da imaju antikancerogena svojstva i sudjeluju u prevenciji
različitih bolesti. Zeljasto povrće je izvor dijetalnih glukozinolata, posebice jedne velike
skupine – sumporni glukozinolati. Ovi spojevi ostaju netaknuti, osim ukoliko nisu u kontaktu
sa enzimom mirozinazom, do kojega dolaze povredom tkiva od strane štetnika ili žvakanjem
istog. Mirozinaza otpušta glukozu i izdvaja izotiocijanate iz povrća.
Izotiocijanati su spojevi sa kemijskom grupom -N = C = S, koja je formirana
zamjenom sumpora za kisik u izocijanat grupi. Povrće sadrži razne glukozinolate, od kojih
svaki hidrolizom tvori drugačiji izotiocijanat. Izotiocijanati poput sulforafana pomažu u
prevenciji raka eliminiranjem mogućih kancerogenih tvari iz tijela. Epidemiološke studije su
dokazale da izloženost ljudi iztiocijanatima, konzumacijom zeljastog povrća, smanjuje rizik
pojave raka, te imaju istovremeno i zaštitnu ulogu. Međutim, iako su prisutni u velikim
količinama, vrlo su osjetljivi spojevi, te kuhanjem, rezanjem i obradom mikrovalovima
smanjuje se njihova bioraspoloživost. |
Abstract (english) | Today, people are increasingly consuming food counting on its ingredients that are found in small quantities, which can have a positive impact on health. Such substances are called biologically active food components. The quality of these substances is not measured by the quantitative representation, but the level of skills that during their biological activity
can counteract the effects of harmful substances in the human body. All biologically active components are different in chemical structure and their function in the body. Some of these ingredients include vitamins, minerals, carotenoids, phenolic compounds, flavonoids, phytosterols, isoflavones, enzymes, tannins, glycosides, alkaloids, and others.
Glucosinolates belong to such substances, which have been extensively studied in the field of nutrition and medicine, and is considered to have anti-cancer properties and participate in the prevention of various diseases. Cruciferous vegetables are a source of dietary glucosinolates, especially a large group - sulfur glucosinolates. These compounds remain intact, unless they are in contact with the enzyme myrosinase, which occurs tissue
injury by pests or chewing it. Myrosinase releases glucose and isothiocyanate extracts from vegetables.
Isothiocyanates are compounds with the chemical group-N = C = S, which is formed by substituting sulfur for oxygen in the isocyanate group. Vegetables contain a variety of glucosinolates, each form a different isothiocyanate by hydrolysis. Isothiocyanates, such as sulforaphane, help prevent cancer by eliminating potential carcinogens from the body.
Epidemiological studies have shown that exposure to isthiocyanates, consumption of green leafy vegetables, reduces cancer risk, and have both a protective role. However, although present in large quantities, they are very sensitive compounds, so cooking, cutting and microwaves reduces their bioavailability. |