The relationship between oral and systemic health has been investigated for a long time. Numerous studies have proved that the periodontal disease is associated with an increased cardiovascular risk. Oral infections and coronary heart disease share their etiology in several aspects. The common two forms of periodontal diseases are chronic and aggressive periodontitis. It occurs mainly in older population, but can also appear in children and adolescents. It is now known that periodontal disease is caused by microorganisms. The inflammatory reaction of oral connective tissue caused by microorganisms results in increased endothelial permeability that allows the migration of bacteria in the perivascular space. The association of poor oral health with cardiovascular disease is reflected in the fact that oral infections can cause inflammation, which may have implications for cardiovascular disease. Today, it can be assumed with certainty that there is a link between periodontal disease and disposal of fatty deposits on arterial walls leading to the occurrence of blood clots that cause atherosclerotic vascular disease. It is considered that in periodontal disease bacteria enter the circulation through the area around the teeth; they are incorporated into the arterial plaques and they worsen the inflammation. In addition to microorganisms, shared risks such as age, gender, smoking, alcohol consumption and socioeconomic status should be mentioned, but we should not forget other possible risk factors of these diseases too.