Orofacial clefts are the most common malformations in the head and face, present in all populations and ethnic groups. It is a disorder that occurs during embryogenesis and therefore the clinical picture is constantly changing until the end of growth and development. Palate clefts can be classified in a variety of ways. According to the side, they are divided into unilateral and bilateral, according to the involvement into complete and partial, and according to the newer developmental-morphological classification, the clefts are divided according to regions into clefts of the primary palate, secondary palate, and a combination of primary and secondary palate. Patients with unilateral or bilateral cleft lip and palate (UCLP and BCLP) often have dental and aesthetic impairments of the midface, dental crossbites, a variety of dental anomalies, asymmetries of the soft tissues, and extraoral and intraoral soft-tissue scarring. Difficulties in eating and speaking are often present, and in some cases, they are accompanied by some other congenital malformations. The treatment of such patients requires a comprehensive interdisciplinary approach from birth in order for them to achieve optimal functional and aesthetic rehabilitation. The treatment of children with cleft lasts from birth to the end of growth. A child at a certain stage of development should be under the supervision of an appropriate specialist. The team collaboration of different specialists is needed, including maxillofacial surgeons, neonatologists, otorhinolaryngologists, pediatricians, speech therapists, dentists, and others. The role of the orthodontist is central to the overall management of treatment. The purpose of this paper is to provide an overview of the possibilities of orthodontic treatment of cleft lip and palate as part of multidisciplinary therapy.