One of the most important clinical phases of fixed prosthodontic therapy is the procedure of fixing the restoration with a suitable material, i.e. cement. The role of cement is to fill the space between the indirect restoration and the abutment tooth, and to ensure stable retention of the restoration in a given position over time. Clinical studies have shown that lack of retention and tooth decay are the main causes of crown and bridge failure. There are many different cements on the market with different properties for specific clinical requirements to choose from. However, this also makes it difficult for the clinician to select the appropriate material. The success of the overall therapy may be compromised by improper choice of the cement and/or non-adherence to prescribed clinical protocols. Therefore, having knowledge of the available cements, their properties, cementing techniques and characteristics of restorative materials is necessary to ensure the success of fixed prosthodontic therapy. As a result of ever-increasing advocacy of minimally invasive dentistry, adhesive cements are growing in popularity in modern fixed prosthodontics. Thus, minimally invasive tooth preparation is a trend that is increasingly present in restorative dentistry and fixed prosthodontics. The possibility of sparing the tooth structure, and a defect-oriented tooth preparation are the biggest advantage of adhesive compared to conventional cementation technique. The purpose of this paper is to present the theoretical foundations of adhesive cementation, the possibilities it offers in fixed prosthodontic therapy, its advantages and disadvantages, and to describe the materials and types of restorations that are indicated for adhesive cementation.