prikaz prve stranice dokumenta Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis
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Scientific paper - Review paper
Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis
Journal of Clinical Medicine, 11 (2022), 7; 1793. https://doi.org/10.3390/jcm11071793
Murthy, Vignesh; Mylonas, Petros; Carey, Barbara; Yogarajah, Sangeetha; Farnell, Damian; Addison, Owen; Cook, Richard; Escudier, Michael; Diniz-Freitas, Marcio; Limeres, Jacobo; Monteiro, Luis; Silva, Luis; Fricain, Jean-Cristophe; Catros, Sylvain; Fenelon, Mathilde; Lodi, Giovanni; Lombardi, Niccolò; Brailo, Vlaho; Ariyaratnam, Raj; López-López, José; Albuquerque, Rui More authors...

Institutional repository: University of Zagreb School of Dental Medicine Repository

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Murthy, V., Mylonas, P., Carey, B., Yogarajah, S., Farnell, D., Addison, O. ... Albuquerque, R. (2022). Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 11. (7). doi: 10.3390/jcm11071793

Murthy, Vignesh, et al. "Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis." Journal of Clinical Medicine, vol. 11, no. 7, 2022. https://doi.org/10.3390/jcm11071793

Murthy, Vignesh, Petros Mylonas, Barbara Carey, Sangeetha Yogarajah, Damian Farnell, Owen Addison, Richard Cook, et al. "Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis." Journal of Clinical Medicine 11, no. 7 (2022). https://doi.org/10.3390/jcm11071793

Murthy, V., et al. (2022) 'Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis', Journal of Clinical Medicine, 11(7). doi: 10.3390/jcm11071793

Murthy V, Mylonas P, Carey B, Yogarajah S, Farnell D, Addison O, and sur.. Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis. Journal of Clinical Medicine [Internet]. 2022 March 24 [cited 2024 December 25];11(7). doi: 10.3390/jcm11071793

V. Murthy, et al., "Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis", Journal of Clinical Medicine, vol. 11, no. 7, March 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:104311. [Accessed: 25 December 2024]

Metadata
Title (english)Malignant Transformation Rate of Oral Submucous Fibrosis: A Systematic Review and Meta-Analysis
AuthorVignesh Murthy
AuthorPetros Mylonas
AuthorBarbara Carey
AuthorSangeetha Yogarajah
AuthorDamian Farnell
AuthorOwen Addison
AuthorRichard Cook
AuthorMichael Escudier
AuthorMarcio Diniz-Freitas
AuthorJacobo Limeres
AuthorLuis Monteiro
AuthorLuis Silva
AuthorJean-Cristophe Fricain
AuthorSylvain Catros
AuthorMathilde Fenelon
AuthorGiovanni Lodi
AuthorNiccolò Lombardi
AuthorVlaho Brailo
AuthorRaj Ariyaratnam
AuthorJosé López-López
AuthorRui Albuquerque
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Oral Medicine
Abstract (english)
Oral submucous fibrosis (OSF) is a chronic progressive condition affecting the oral cavity, oropharynx and upper third of the oesophagus. It is a potentially malignant disorder. The authors collated and analysed the existing literature to establish the overall malignant transformation rate (MTR). A retrospective analysis of medical and dental scientific literature using online indexed databases was conducted for the period 1956 to 2021. The quality of the enrolled studies was assessed by the Newcastle-Ottawa Scale (NOS). A meta-analysis using a random effects model of a single proportion was performed along with statistical tests for heterogeneity. The overall proportion of malignancy across all studies was 0.06 (95% CI, 0.02–0.10), indicating an overall 6% risk of malignant transformation across all studies and cohorts. Sub-group analyses revealed strong differences in proportion of malignancy according to ethnicity/cohort; Chinese = 0.02 (95% CI 0.01–0.02), Taiwanese = 0.06 (95% CI, 0.03–0.10), Indian = 0.08 (95% CI, 0.03–0.14) and Pakistani = 0.27 (95% CI 0.25–0.29). Overall, the MTR was 6%; however, wide heterogeneity of the included studies was noted. Geographic variations in MTR were noted but were not statistically significant. Further studies are required to analyse the difference between cohort groups.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 11, no. 7, 1793
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm11071793
URN:NBNurn:nbn:hr:127:104311
Publication2022-03-24
Document URLhttps://www.mdpi.com/2077-0383/11/7/1793
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-11-02 07:59:03