prikaz prve stranice dokumenta Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157
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Scientific paper - Original scientific paper
Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157
Biomedicines, 9 (2021), 10; 1300. https://doi.org/10.3390/biomedicines9101300
Gojković, Slaven; Krežić, Ivan; Vraneš, Hrvoje; Žižek, Helena; Drmić, Domagoj; Batelja Vuletić, Lovorka; Milavić, Marija; Sikirić, Sunčana; Stilinović, Irma; Simeon, Paris; Knežević, Mario; Kolak, Toni; Tepeš, Marijan; Simonji, Karol; Štrbe, Sanja; Nikolac Gabaj, Nora; Barišić, Ivan; Orešković, Emma Grace; Lovrić, Eva; Kokot, Antonio; Škrtić, Anita; Boban Blagaić, Alenka; Seiwerth, Sven; Sikirić, Predrag More authors...

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Gojković, S., Krežić, I., Vraneš, H., Žižek, H., Drmić, D., Batelja Vuletić, L. ... Sikirić, P. (2021). Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157. Biomedicines, 9. (10). doi: 10.3390/biomedicines9101300

Gojković, Slaven, et al. "Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157." Biomedicines, vol. 9, no. 10, 2021. https://doi.org/10.3390/biomedicines9101300

Gojković, Slaven, Ivan Krežić, Hrvoje Vraneš, Helena Žižek, Domagoj Drmić, Lovorka Batelja Vuletić, Marija Milavić, et al. "Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157." Biomedicines 9, no. 10 (2021). https://doi.org/10.3390/biomedicines9101300

Gojković, S., et al. (2021) 'Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157', Biomedicines, 9(10). doi: 10.3390/biomedicines9101300

Gojković S, Krežić I, Vraneš H, Žižek H, Drmić D, Batelja Vuletić L, and sur.. Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157. Biomedicines [Internet]. 2021 September 23 [cited 2025 April 02];9(10). doi: 10.3390/biomedicines9101300

S. Gojković, et al., "Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157", Biomedicines, vol. 9, no. 10, September 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:955905. [Accessed: 02 April 2025]

Metadata
Title (english)Robert’s Intragastric Alcohol-Induced Gastric Lesion Model as an Escalated General Peripheral and Central Syndrome, Counteracted by the Stable Gastric Pentadecapeptide BPC 157
AuthorSlaven Gojković
AuthorIvan Krežić
AuthorHrvoje Vraneš
AuthorHelena Žižek
AuthorDomagoj Drmić
AuthorLovorka Batelja Vuletić
AuthorMarija Milavić
AuthorSunčana Sikirić
AuthorIrma Stilinović
AuthorParis Simeon
AuthorMario Knežević
AuthorToni Kolak
AuthorMarijan Tepeš
AuthorKarol Simonji
AuthorSanja Štrbe
MBZ: 319335
AuthorNora Nikolac Gabaj
AuthorIvan Barišić
AuthorEmma Grace Orešković
AuthorEva Lovrić
AuthorAntonio Kokot
AuthorAnita Škrtić
AuthorAlenka Boban Blagaić
AuthorSven Seiwerth
AuthorPredrag Sikirić
Author's institution(Merkur University Hospital)
Author's institution(Clinical hospital center Osijek)
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionJosip Juraj Strossmayer University of Osijek
Faculty of Medicine Osijek
(Department of Pharmacology)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Author's institutionUniversity of Zagreb
School of Dental Medicine
(Department of Endodontics and Restorative Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We redefined Robert’s prototypical cytoprotection model, namely the intragastric administration of 96% alcohol in order to generate a general peripheral and central syndrome similar to that which occurs when major central or peripheral veins are occluded in animal models. With this redefinition, we used Robert’s model to examine the cytoprotective effects of the stable gastric pentadecapeptide BPC 157. The intragastric administration of alcohol induced gastric lesions, intracranial (superior... More sagittal sinus) hypertension, severe brain swelling and lesions, portal and vena caval hypertension, aortal hypotension, severe thrombosis, inferior vena cava and superior mesenteric vein congestion, azygos vein failure (as a failed collateral pathway), electrocardiogram disturbances, and heart, lung, liver and kidney lesions. The use of BPC 157 therapy (10 µg/kg or 10 ng/kg given intraperitoneally 1 min after alcohol) counteracted these deficits rapidly. Specifically, BPC 157 reversed brain swelling and superior mesenteric vein and inferior vena caval congestion, and helped the azygos vein to recover, which improved the collateral blood flow pathway. Microscopically, BPC 157 counteracted brain (i.e., intracerebral hemorrhage with degenerative changes of cerebral and cerebellar neurons), heart (acute subendocardial infarct), lung (parenchymal hemorrhage), liver (congestion), kidney (congestion) and gastrointestinal (epithelium loss, hemorrhagic gastritis) lesions. In addition, this may have taken place along with the activation of specific molecular pathways. In conclusion, these findings clarify and extend the theory of cytoprotection, offer an approach to its practical application, and establish BPC 157 as a prospective cytoprotective treatment. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 9, no. 10, 1300
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines9101300
URN:NBNurn:nbn:hr:127:955905
Publication2021-09-23
Document URLhttps://www.mdpi.com/2227-9059/9/10/1300
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-11-04 08:59:35
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