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Scientific paper - Original scientific paper
Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites
Pharmaceutics, 14 (2022), 10; 2241. https://doi.org/10.3390/pharmaceutics14102241
Munir, Arooj; Marović, Danijela; Nogueira, Liebert Parreiras; Simm, Roger; Naemi, Ali-Oddin; Landrø, Sander Marius; Helgerud, Magnus; Zheng, Kai; Par, Matej; Tauböck, Tobias T.; Attin, Thomas; Tarle, Zrinka; Boccaccini, Aldo R.; Haugen, Håvard J.

Institutional repository: University of Zagreb School of Dental Medicine Repository

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Munir, A., Marović, D., Nogueira, L. P., Simm, R., Naemi, A. O., Landrø, S. M. ... Haugen, H. J. (2022). Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites. Pharmaceutics, 14. (10). doi: 10.3390/pharmaceutics14102241

Munir, Arooj, et al. "Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites." Pharmaceutics, vol. 14, no. 10, 2022. https://doi.org/10.3390/pharmaceutics14102241

Munir, Arooj, Danijela Marović, Liebert Parreiras Nogueira, Roger Simm, Ali Oddin Naemi, Sander Marius Landrø, Magnus Helgerud, et al. "Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites." Pharmaceutics 14, no. 10 (2022). https://doi.org/10.3390/pharmaceutics14102241

Munir, A., et al. (2022) 'Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites', Pharmaceutics, 14(10). doi: 10.3390/pharmaceutics14102241

Munir A, Marović D, Nogueira LP, Simm R, Naemi AO, Landrø SM, and sur.. Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites. Pharmaceutics [Internet]. 2022 October 20 [cited 2024 November 08];14(10). doi: 10.3390/pharmaceutics14102241

A. Munir, et al., "Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites", Pharmaceutics, vol. 14, no. 10, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:422035. [Accessed: 08 November 2024]

Metadata
Title (english)Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites
AuthorArooj Munir
AuthorDanijela Marović
AuthorLiebert Parreiras Nogueira
AuthorRoger Simm
AuthorAli-Oddin Naemi
AuthorSander Marius Landrø
AuthorMagnus Helgerud
AuthorKai Zheng
AuthorMatej Par
AuthorTobias T. Tauböck
AuthorThomas Attin
AuthorZrinka Tarle
AuthorAldo R. Boccaccini
AuthorHåvard J. Haugen
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Endodonics and Restorative Dentistry
Abstract (english)
Experimental dental resin composites containing copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were developed to impart anti-bacterial properties. Increasing amounts of Cu-MBGN (0, 1, 5 and 10 wt%) were added to the BisGMA/TEGDMA resin matrix containing micro- and nano-fillers of inert glass, keeping the resin/filler ratio constant. Surface micromorphology and elemental analysis were performed to evaluate the homogeneous distribution of filler particles. The study investigated the effects of Cu-MBGN on the degree of conversion, polymerization shrinkage, porosity, ion release and anti-bacterial activity on S. mutans and A. naeslundii. Experimental materials containing Cu-MBGN showed a dose-dependent Cu release with an initial burst and a further increase after 28 days. The composite containing 10% Cu-MBGN had the best anti-bacterial effect on S. mutans, as evidenced by the lowest adherence of free-floating bacteria and biofilm formation. In contrast, the 45S5-containing materials had the highest S. mutans adherence. Ca release was highest in the bioactive control containing 15% 45S5, which correlated with the highest number of open porosities on the surface. Polymerization shrinkage was similar for all tested materials, ranging from 3.8 to 4.2%, while the degree of conversion was lower for Cu-MBGN materials. Cu-MBGN composites showed better anti-bacterial properties than composites with 45S5 BG.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePharmaceutics
Numberingvol. 14, no. 10, 2241
e-ISSN1999-4923
DOIhttps://doi.org/10.3390/pharmaceutics14102241
URN:NBNurn:nbn:hr:127:422035
Publication2022-10-20
Document URLhttps://www.mdpi.com/1999-4923/14/10/2241
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-11-07 10:07:18