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Scientific paper - Original scientific paper
Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients
Journal of Clinical Medicine, 10 (2021), 18; 4222. https://doi.org/10.3390/jcm10184222
Paštrović, Frane; Lucijanić, Marko; Atić, Armin; Stojić, Josip; Barišić Jaman, Mislav; Tješić Drinković, Ida; Zelenika, Marko; Milošević, Marko; Medić, Barbara; Lončar, Jelena; Mijić, Maja; Filipec Kanižaj, Tajana; Kralj, Dominik; Lerotić, Ivan; Virović Jukić, Lucija; Ljubičić, Neven; Luetić, Krešimir; Grgić, Dora; Majerović, Matea; Ostojić, Rajko; Krznarić, Željko; Lukšić, Ivica; Piskač Živković, Nevenka; Kereš, Tatjana; Grabovac, Vlatko; Peršec, Jasminka; Baršić, Bruno; Grgurević, Ivica More authors...

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Paštrović, F., Lucijanić, M., Atić, A., Stojić, J., Barišić Jaman, M., Tješić Drinković, I. ... Grgurević, I. (2021). Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients. Journal of Clinical Medicine, 10. (18). doi: 10.3390/jcm10184222

Paštrović, Frane, et al. "Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients." Journal of Clinical Medicine, vol. 10, no. 18, 2021. https://doi.org/10.3390/jcm10184222

Paštrović, Frane, Marko Lucijanić, Armin Atić, Josip Stojić, Mislav Barišić Jaman, Ida Tješić Drinković, Marko Zelenika, et al. "Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients." Journal of Clinical Medicine 10, no. 18 (2021). https://doi.org/10.3390/jcm10184222

Paštrović, F., et al. (2021) 'Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients', Journal of Clinical Medicine, 10(18). doi: 10.3390/jcm10184222

Paštrović F, Lucijanić M, Atić A, Stojić J, Barišić Jaman M, Tješić Drinković I, and sur.. Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients. Journal of Clinical Medicine [Internet]. 2021 September 17 [cited 2024 November 23];10(18). doi: 10.3390/jcm10184222

F. Paštrović, et al., "Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients", Journal of Clinical Medicine, vol. 10, no. 18, September 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:753957. [Accessed: 23 November 2024]

Metadata
Title (english)Prevalence and Prognostic Impact of Deranged Liver Blood Tests in COVID-19: Experience from the Regional COVID-19 Center over the Cohort of 3812 Hospitalized Patients
AuthorFrane Paštrović
AuthorMarko Lucijanić
AuthorArmin Atić
AuthorJosip Stojić
AuthorMislav Barišić Jaman
AuthorIda Tješić Drinković
AuthorMarko Zelenika
AuthorMarko Milošević
AuthorBarbara Medić
AuthorJelena Lončar
AuthorMaja Mijić
AuthorTajana Filipec Kanižaj
AuthorDominik Kralj
AuthorIvan Lerotić
AuthorLucija Virović Jukić
AuthorNeven Ljubičić
AuthorKrešimir Luetić
AuthorDora Grgić
AuthorMatea Majerović
AuthorRajko Ostojić
AuthorŽeljko Krznarić
MBZ: 75865
AuthorIvica Lukšić
AuthorNevenka Piskač Živković
AuthorTatjana Kereš
AuthorVlatko Grabovac
AuthorJasminka Peršec
AuthorBruno Baršić
AuthorIvica Grgurević
Author's institution(Merkur University Hospital)
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionUniversity of Zagreb
School of Medicine
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Background: Derangement of liver blood tests (LBT) is frequent in patients with Coronavirus disease 2019 (COVID-19). We aimed to evaluate (a) the prevalence of deranged LBT as well as their association with (b) clinical severity at admission and (c) 30-day outcomes among the hospitalized patients with COVID-19. Methods: Consecutive patients with COVID-19 hospitalized in the regional referral center over the 12-month period were included. Clinical severity of COVID-19 at hospital admission and 30-day outcomes (need for intensive care, mechanical ventilation, or death) were analyzed. Results: Derangement of LBT occurred in 2854/3812 (74.9%) of patients, most frequently due to elevation of AST (61.6%), GGT (46.1%) and ALT (33.4%). Elevated AST, ALT, GGT and low albumin were associated with more severe disease at admission. However, in multivariate Cox regression analysis, when adjusted for age, sex, obesity and presence of chronic liver disease, only AST remained associated with the risk of dying (HR 1.5081 and 2.1315, for elevations 1–3 × ULN and >3 × ULN, respectively) independently of comorbidity burden and COVID-19 severity at admission. Patients with more severe liver injury more frequently experienced defined adverse outcomes. Conclusions: Deranged LBTs are common among patients hospitalized with COVID-19 and might be used as predictors of adverse clinical outcomes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Clinical Medicine
Numberingvol. 10, no. 18, 4222
e-ISSN2077-0383
DOIhttps://doi.org/10.3390/jcm10184222
URN:NBNurn:nbn:hr:127:753957
Publication2021-09-17
Document URLhttps://www.mdpi.com/2077-0383/10/18/4222
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-11-07 10:55:13