prikaz prve stranice dokumenta Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans
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Scientific paper - Original scientific paper
Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans
Bioengineering, 9 (2022), 10; 566. https://doi.org/10.3390/bioengineering9100566
Duplančić, Roko; Roguljić, Marija; Božić, Darko; Kero, Darko

Institutional repository: University of Zagreb School of Dental Medicine Repository

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Duplančić, R., Roguljić, M., Božić, D. & Kero, D. (2022). Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans. Bioengineering, 9. (10). doi: 10.3390/bioengineering9100566

Duplančić, Roko, et al. "Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans." Bioengineering, vol. 9, no. 10, 2022. https://doi.org/10.3390/bioengineering9100566

Duplančić, Roko, Marija Roguljić, Darko Božić and Darko Kero. "Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans." Bioengineering 9, no. 10 (2022). https://doi.org/10.3390/bioengineering9100566

Duplančić, R., et al. (2022) 'Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans', Bioengineering, 9(10). doi: 10.3390/bioengineering9100566

Duplančić R, Roguljić M, Božić D, Kero D. Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans. Bioengineering [Internet]. 2022 October 18 [cited 2024 April 18];9(10). doi: 10.3390/bioengineering9100566

R. Duplančić, M. Roguljić, D. Božić and D. Kero, "Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans", Bioengineering, vol. 9, no. 10, October 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:109850. [Accessed: 18 April 2024]

Metadata
Title (english)Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans
AuthorRoko Duplančić
AuthorMarija Roguljić
AuthorDarko Božić
AuthorDarko Kero
Author's institutionUniversity of Split
Author's institution(University Hospital of Split)
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Periodontology
Abstract (english)
Since chronically inflamed periodontal tissue exhibits extracellular matrix (ECM) degradation, the possible alternative to standard periodontitis treatment is to restore ECM by supplementing its components, including heparan sulfate glycosaminoglycan (HS GAG). Supplementation of the degraded ECM with synthetic derivatives of HS GAGs has been shown to be effective for periodontal tissue regeneration in experimental animal models of periodontitis. However, the potential of HS GAG supplementation for the treatment of periodontal disease in humans is still unknown. Here, we used a statistical model to investigate the role of HS GAG on inflammatory infiltrate formation and alveolar bone resorption in humans with severe periodontitis. The model was based on data from immunofluorescence staining (IF) of human gingiva samples, and reconstruction of a subset of HS GAG -related proteins from STRING reactome database. According to predictions, increased expression of native HS GAG might stabilize the accumulation of gingival inflammatory infiltrate (represented by the general inflammatory cell marker CD45) and alveolar bone resorption (represented by Receptor Activator of Nuclear ΚΒ ligand (RANKL) and osteoprotegerin (OPG) ratio) but could not restore them to healthy tissue levels. Therefore, supplementation of native HS GAG may be of limited benefits for the treatment of sever periodontitis in humans.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBioengineering
Numberingvol. 9, no. 10, 566
e-ISSN2306-5354
DOIhttps://doi.org/10.3390/bioengineering9100566
URN:NBNurn:nbn:hr:127:109850
Publication2022-10-18
Document URLhttps://www.mdpi.com/2306-5354/9/10/566
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-11-10 10:16:42