New oral anticoagulant drugs are being increasingly used in patients with a risk of thromboembolism. The primary function of these drugs is the influence on the coagulation mechanism by blocking some of the blood clotting factors and thereby preventing the formation of a blood clot. Due to their stable pharmacokinetics and pharmacodynamics, there is no need for regular blood clotting control. There are two groups of NOACs: direct thrombin inhibitors which include dabigatran and direct FXa inhibitors which include apixaban, rivaroxaban and edoxaban. Invasive dental procedures in which bleeding is not expected or procedures in which the risk of prolonged bleeding is minimal can be performed without discontinuation of the NOACs therapy. Procedures which have a high risk of prolonged bleeding demand consultations about the discontinuation of the therapy with the competent doctor who has prescribed it. Patients with a certain degree of renal impairment also need a dose modification or therapy discontinuation due to the longer retention of the active substance of NOAK in the blood plasma. After surgery, it is preferable to apply several measures of local haemostasis, which, in addition to tamponade with sterile gauze, include the placement of sutures, and if possible, the application of some antifibrinolytic and absorbent sponge agent.