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master's thesis
Uloga vitamina D u cijeljenju rane
Zagreb: University of Zagreb, School of Dental Medicine, 2022. urn:nbn:hr:127:470547
Cikojević, Antea
University of Zagreb
School of Dental Medicine
Department of Oral Surgery

Institutional repository: University of Zagreb School of Dental Medicine Repository

Cite this document

Cikojević, A. (2022). Uloga vitamina D u cijeljenju rane (Master's thesis). Zagreb: University of Zagreb, School of Dental Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:127:470547

Cikojević, Antea. "Uloga vitamina D u cijeljenju rane." Master's thesis, University of Zagreb, School of Dental Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:127:470547

Cikojević, Antea. "Uloga vitamina D u cijeljenju rane." Master's thesis, University of Zagreb, School of Dental Medicine, 2022. https://urn.nsk.hr/urn:nbn:hr:127:470547

Cikojević, A. (2022). 'Uloga vitamina D u cijeljenju rane', Master's thesis, University of Zagreb, School of Dental Medicine, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:127:470547

Cikojević A. Uloga vitamina D u cijeljenju rane [Master's thesis]. Zagreb: University of Zagreb, School of Dental Medicine; 2022 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:127:470547

A. Cikojević, "Uloga vitamina D u cijeljenju rane", Master's thesis, University of Zagreb, School of Dental Medicine, Zagreb, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:127:470547

Metadata
TitleUloga vitamina D u cijeljenju rane
Title (english)The role of vitamin D in wound healing
AuthorAntea Cikojević
MentorMarko Granić (mentor)
Committee memberMarko Granić (predsjednik povjerenstva)
Committee memberLarisa Musić (član povjerenstva)
Committee memberDomagoj Vražić (član povjerenstva)
GranterUniversity of Zagreb
School of Dental Medicine
(Department of Oral Surgery)
Zagreb
Defense date and country2022-09-30, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Oral Surgery
Abstract
Vitamin D steroidni je hormon koji ima ključnu ulogu u održavanju homeostaze kostiju i kalcija. Najvećim dijelom vitamin D dobijemo putem kože, sintezom sunčevih zraka, dok manji dio dobijemo putem prehrane. Tako razlikujemo dva oblika: Kolekalciferol (vitamin D3), koji se unosi iz namirnica životinjskog podrijetla, i Ergokalciferol (vitamin D2), koji se unosi iz namirnicama biljnog podrijetla. Oba oblika su neaktivna. Da bi postali aktivni prvo podliježu procesu hidroksilacije u jetri prilikom koje nastaje Kalcidiol, a potom hidroksilaciji u bubregu gdje nastaje Kalcitriol, njegov aktivni metabolit. U ovom obliku funkcionira kao ligand za VDR (receptor vitamina D). Najbolji pokazatelj statusa vitamina D u ljudskom tijelu je koncentracija 25(OH)D u serumu. Nedostatak vitamina D u odraslih može dovesti do osteomalacije, dok kod djece dovodi do rahitisa. Veza vitamina D i cijeljenja rana je posljednjih godina predmet brojnih istraživanja. Cijeljenje je proces koji se događa za vrijeme trajanja upale. Ono je ključno za preživljavanje organizma budući da mu je krajnji cilj popravak arhitekture tkiva i vraćanje prvobitne funkcije. U ovom procesu sudjeluju brojni regulacijski mehanizmi, a temelje se na proliferaciji i diferencijaciji nekoliko vrsta stanica i njihovoj interakciji s ekstracelularnim matriksom. Razlikujemo tri vrste cijeljenja: primarno, sekundarno i tercijarno, dok proces zacjeljivanja rana kod odraslih možemo podijeliti u tri faze: upalnu, fibroblastičnu i fazu sazrijevanja.
Abstract (english)
Vitamin D is a steroid hormone with a key role in the maintenance of bone and calcium homeostasis. Most of vitamin D in humans is synthesized in the skin via sun exposure, with a smaller amount derived from diet. We distinguish two forms based on their origin: cholecalciferol (vitamin D3) –from animal source foods, and ergocalciferol (vitamin D2) –from plant source foods. Both forms are inactive. They are activated through the process of hydroxylation in the liver, where calcifediol is produced, and in the kidneys, where calcitriol, its active metabolite, is produced. In this form, it functions as a ligand for the VDR (vitamin D receptor). The best indicator of vitamin D levels in the human body is the total serum concentration of 25(OH)D. Vitamin D deficiency can cause osteomalacia in adults and rickets in children. The correlation between vitamin D and wound healing has been a frequent subject of research in the last few years. Wound healing is a process which occurs during the period of inflammation. It is crucial for survival since it aims to repair the tissue architecture and restore its primary function. Numerous regulatory mechanisms participate in this process. They are based on the proliferation and differentiation of several cell types and their interaction with the extracellular matrix. There are three types of healing: primary, secondary and tertiary. The process of wound healing in adults can be divided into three phases: inflammatory, fibroblastic and scar maturation.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:127:470547
Study programmeTitle: dental medicine
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: doktor/doktorica dentalne medicine (doktor/doktorica dentalne medicine)
Type of resourceText
File originBorn digital
Access conditionsAccess restricted to students and staff of home institution
Terms of useLicence In copyright icon
Created on2022-12-06 10:08:06