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doctoral thesis
Povezanost koncentracije salivarnoga melatonina, kvalitete sna i kvalitete života s težinom kliničke slike kronične spontane urtikarije
Zagreb: University of Zagreb, School of Dental Medicine, 2023. urn:nbn:hr:127:409227
Bešlić, Iva
University of Zagreb
School of Dental Medicine
Chair of Dermatovenerology

Institutional repository: University of Zagreb School of Dental Medicine Repository

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Bešlić, I. (2023). Povezanost koncentracije salivarnoga melatonina, kvalitete sna i kvalitete života s težinom kliničke slike kronične spontane urtikarije (Doctoral thesis). Zagreb: University of Zagreb, School of Dental Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:127:409227

Bešlić, Iva. "Povezanost koncentracije salivarnoga melatonina, kvalitete sna i kvalitete života s težinom kliničke slike kronične spontane urtikarije." Doctoral thesis, University of Zagreb, School of Dental Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:127:409227

Bešlić, Iva. "Povezanost koncentracije salivarnoga melatonina, kvalitete sna i kvalitete života s težinom kliničke slike kronične spontane urtikarije." Doctoral thesis, University of Zagreb, School of Dental Medicine, 2023. https://urn.nsk.hr/urn:nbn:hr:127:409227

Bešlić, I. (2023). 'Povezanost koncentracije salivarnoga melatonina, kvalitete sna i kvalitete života s težinom kliničke slike kronične spontane urtikarije', Doctoral thesis, University of Zagreb, School of Dental Medicine, accessed 04 November 2024, https://urn.nsk.hr/urn:nbn:hr:127:409227

Bešlić I. Povezanost koncentracije salivarnoga melatonina, kvalitete sna i kvalitete života s težinom kliničke slike kronične spontane urtikarije [Doctoral thesis]. Zagreb: University of Zagreb, School of Dental Medicine; 2023 [cited 2024 November 04] Available at: https://urn.nsk.hr/urn:nbn:hr:127:409227

I. Bešlić, "Povezanost koncentracije salivarnoga melatonina, kvalitete sna i kvalitete života s težinom kliničke slike kronične spontane urtikarije", Doctoral thesis, University of Zagreb, School of Dental Medicine, Zagreb, 2023. Available at: https://urn.nsk.hr/urn:nbn:hr:127:409227

Metadata
TitlePovezanost koncentracije salivarnoga melatonina, kvalitete sna i kvalitete života s težinom kliničke slike kronične spontane urtikarije
Title (english)Salivary melatonin levels in correlation with sleep quality, quality of life and clinical features in patients with chronic spontaneous urticaria
AuthorIva Bešlić
MentorLiborija Lugović Mihić (mentor)
Committee memberMirna Šitum (predsjednik povjerenstva)
Committee memberMarija Buljan (član povjerenstva)
Committee memberRomana Čeović (član povjerenstva)
Committee memberIvan Salarić (član povjerenstva)
GranterUniversity of Zagreb
School of Dental Medicine
(Chair of Dermatovenerology)
Zagreb
Defense date and country2023-12-12, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Universal decimal classification
(UDC)		61 - Medical sciences
Abstract
Uvod: U većine bolesnika s kroničnom spontanom urtikarijom (KSU), veliki problem predstavlja svrbež koji se učestalije javlja u večernjim i noćnim satima što uzrokuje poteškoće sa spavanjem. Za postizanje dobre kvalitete sna (KS) je ključan melatonin, hormon koji sudjeluje u započinjanju i održavanju ciklusa spavanja te je izuzetno bitna njegova adekvatna proizvodnja. Cilj ovog istraživanja je bio ispitati vrijednosti salivarnoga melatonina te povezanost težine bolesti i poremećaja kvalitete života (KŽ) i KS u tih bolesnika. Metodologija: U 38 bolesnika s KSU-om i 38 ispitanika kontrolne skupine određivan je salivarni melatonin (ELISA), KŽ (“Dermatology Quality of Life”) i KS (“Pittsburgh Sleep Quality Index”), a u bolesnika s KSU-om je dodatno određivana težina (“Urticaria Activity Score”) i kontrola bolesti (“Urticaria Control Test”). Rezultati: Sniženi salivarni melatonin je uočen u 34/38 bolesnika s KSU. Teški oblik urtikarije imalo je 12/38 ispitanika, a značajno narušenu KŽ 8/38 bolesnika. Težina urtikarije je linearno proporcionalno povezana s KŽ i KS u tih bolesnika, uz jaku korelaciju s KŽ i slabu korelaciju s KS, dok koncentracija salivarnoga melatonina nije povezana ni s KS ni s KŽ. Zaključak: Ovo su prvi literaturni podaci u svijetu o sniženim vrijednostima melatonina, salivarnog biomarkera poremećaja spavanja, u bolesnika s KSU-om.
Abstract (english)
Introduction: For the majority of patients with chronic spontaneous urticaria (CSU), a big problem is the nocturnal itch, which leads to sleep disturbance. Melatonin regulates promoting and maintaining the sleep cycle and its adequate production is crucial for good sleep quality (SQ). The aim of this study was to examine salivary melatonin and the association between disease severity, quality of life (QoL) and SQ in these patients. Methodology: Salivary melatonin (ELISA), QoL (“Dermatology Quality of Life”) and SQ (“Pittsburgh Sleep Quality Index “) were determined in 38 patients with CSU and 38 healthy subjects. In patients with CSU, the severity of the urticaria (“Urticaria Activity Score”) and the disease control (“Urticaria Control Test”) were additionally determined. Results: Decreased salivary melatonin was observed in 34/38 patients with CSU. Severe form of urticaria was detected in 12/38 patients and QoL was significantly impaired in 8/38 patients. The severity of urticaria was linearly proportional to QoL and SQ in these patients, with a strong correlation with QoL and a weak correlation with SQ, while the salivary melatonin was not related to QoL nor SQ. Conclusion: These are the first literature data in the world indicating decreased levels of the salivary melatonin in patients with CSU.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:127:409227
Promotion2023
Study programmeTitle: Obtaining a doctorate of science outside of doctoral studies
Study programme type: university
Study level: postgraduate
Academic / professional title: doktor/doktorica znanosti (doktor/doktorica znanosti)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2023-01-02 09:11:20