Tooth autotransplantation is a surgical method in which a patient's own tooth is transplanted into a surgically prepared alveolus or into a post-extractional alveolus in the same or the opposite jaw of the donor tooth. The main goal of this surgical procedure is to recover the aesthetic, masticatory and fonetic function of the previously lost tooth. The procedure is usually done when a certain tooth has a bad long-term prognosis, has endured significant trauma or is severely affected by caries. The surgical procedure includes extraction of the tooth in the recipient site and surgical processing of the surrounding alveolus corresponding to the dimensions of the donor tooth. Tooth transplantation restores the function of the lost tooth and allows its supporting bone to maintain its dimensions and size. Besides autotransplantation and fixed prosthetics, in today's era, a lost tooth can be compensated with dental implants, which have a good long-term prognosis/results and are simply inserted into the bone. Evolvement of the new radiological methods, primarily the developement of CBCT images, allows the surgeon to see the patient's bone three-dimensionally, which enables him to measure the dimensions of the donor tooth and the distance from the surrounding anatomical structures, as well as to makes the preoperative planning easier and more precise altogether. Progression of computer technologies and science resulted in CAD/CAM systems, in which the operator can make full-sized replicas of the donor tooth that will be used as an individualised template guide for bone processing which will shorten extra-alveolar time and potential iatrogenic damages to periodontal cells on the roots of the donor tooth. With the use of replicas, chances of patients' rejecting the transplanted tooth are reduced and the overall success rate of the therapy is increases. In today's era, autotransplantation is used again as a great option for missing teeth, especially in younger population, where dental implants are contraindicated.