Bioactive materials are becoming more frequently used in endodontics. We refer to these materials as the ones capable of stimulating the specific biological response and creating a bond between the tooth's hard tissue and the material itself. Bioactive materials are manufactured in different forms and distinct composition and they are being used as materials for indirect and direct pulp capping procedure, orthograde and retrograde root canal obturation, closure of root perforations, apexification and apexogenesis on the grounds that these materials, in contrast to traditional endodontic sealers, prompt the differentiation of osteoblastic type cells which contribute to faster and better healing of the periapical tissue. These materials are capable of releasing calcium ions as well as forming a calcium hydroxide layer. Hydraulic calcium silicate cements and materials based on bioactive glass are included in this classification. The major advantages of these materials are that they induce tissue healing when in contact with the periapical tissue, formation of the mineralized zone, nontoxicity, osteoinduction, osteoconduction, accelerated tissue healing, decreasing the probability of microleakage effect as well as exhibiting a favourable bonding strength.