Marsupialization is the surgical procedure of opening the cyst to establish its communication with the outside space. Cysts of the orofacial region are very often asymptomatic, due to which, at the time of diagnosis, it is no longer possible to simply enucleate them and expect them to heal through a blood clot. This is exactly why marsupialization or the Partsch I method is one of the possible treatment options that aims to remove the cystic cavity with minimal removal of the surrounding bone, thereby preventing possible complications in the form of a pathological bone fracture or recurrence due to incomplete removal of the cyst capsule. The first step in cyst therapy, naturally, is to establish an exhaustive diagnosis, which nowadays is reached with the help of numerous complementary methods. Since the maxillofacial region is more frequently affected by cysts than other parts of the body, different classifications of jaw cysts have been established throughout history, of which the most important divisions will be presented in this paper. The aim of this paper is to show the significance of marsupialization as a therapeutic procedure in the treatment of a large mandibular cyst in a 44-year-old patient.