During endodontic therapy, effective management of infection and pain is essential. Research suggests that 20% of patients experience pain after endodontic procedures. Based on recent meta-analyses, a combination of ibuprofen and paracetamol is the most effective approach for relieving postoperative endodontic pain. It is recommended to administer the first dose of analgesics before the loss of local anesthesia and to follow a scheduled dosing regimen rather than taking medication as needed. In cases of severe postoperative pain, alternative drug classes are considered. In endodontic infections, the objectives of treatment are to eliminate pathogenic microorganisms, bacterial toxins, and necrotic tissue from the contaminated root canal system, which creates an environment that supports healing. This is achieved through mechanical debridement and chemical disinfection of the root canals, as well as establishing proper drainage from both soft and hard tissues. Antibiotics are indicated as adjuvant therapy in endodontics in specific cases, such as presence of systemic symptoms and diffuse spread of infection. According to current studies, prescription durations of 2 to 3 days, until symptom resolution, are as effective as longer courses. Prolonged exposure to antibiotics can lead to the development of antibiotic resistance and side effects because of the reduction of normal gastrointestinal microbiota. Amoxicillin, possibly combined with metronidazole, is the preferred antibiotic against odontogenic microorganisms. When treating patients, it is important to prioritize individualized management of pain and infections. This involves carefully assessing the effectiveness and safety of analgesics and antibiotics.