prikaz prve stranice dokumenta Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry
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Scientific paper - Original scientific paper
Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry
Cells, 12 (2023), 14; 12141841. https://doi.org/10.3390/cells12141841
Krasic, Jure; Skara Abramovic, Lucija; Himelreich Peric, Marta; Vanjorek, Vedran; Gangur, Marko; Zovko, Dragana; Malnar, Marina; Masic, Silvija; Demirovic, Alma; Juric, Bernardica; Ulamec, Monika; Coric, Marijana; Jezek, Davor; Kulis, Tomislav; Sincic, Nino More authors...

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Krasic, J., Skara Abramovic, L., Himelreich Peric, M., Vanjorek, V., Gangur, M., Zovko, D. ... Sincic, N. (2023). Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry. Cells, 12. (14). doi: 10.3390/cells12141841

Krasic, Jure, et al. "Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry." Cells, vol. 12, no. 14, 2023. https://doi.org/10.3390/cells12141841

Krasic, Jure, Lucija Skara Abramovic, Marta Himelreich Peric, Vedran Vanjorek, Marko Gangur, Dragana Zovko, Marina Malnar, et al. "Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry." Cells 12, no. 14 (2023). https://doi.org/10.3390/cells12141841

Krasic, J., et al. (2023) 'Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry', Cells, 12(14). doi: 10.3390/cells12141841

Krasic J, Skara Abramovic L, Himelreich Peric M, Vanjorek V, Gangur M, Zovko D, and sur.. Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry. Cells [Internet]. 2023 July 13 [cited 2024 April 28];12(14). doi: 10.3390/cells12141841

J. Krasic, et al., "Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry", Cells, vol. 12, no. 14, July 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:136123. [Accessed: 28 April 2024]

Metadata
Title (english)Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry
AuthorJure Krasic
AuthorLucija Skara Abramovic
AuthorMarta Himelreich Peric
AuthorVedran Vanjorek
AuthorMarko Gangur
AuthorDragana Zovko
AuthorMarina Malnar
AuthorSilvija Masic
AuthorAlma Demirovic
AuthorBernardica Juric
AuthorMonika Ulamec
AuthorMarijana Coric
AuthorDavor Jezek
AuthorTomislav Kulis
AuthorNino Sincic
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institution(Zagreb University Hispital Center)
Author's institutionUniversity of Zagreb
School of Dental Medicine
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The accurate management of testicular germ cell tumors (TGCTs) depends on identifying the individual histological tumor components. Currently available data on protein expression in TGCTs are limited. The human protein atlas (HPA) is a comprehensive resource presenting the expression and localization of proteins across tissue types and diseases. In this study, we have compared the data from the HPA with our in-house immunohistochemistry on core TGCT diagnostic genes to test reliability and potential biomarker genes. We have compared the protein expression of 15 genes in TGCT patients and non-neoplastic testicles with the data from the HPA. Protein expression was converted into diagnostic positivity. Our study discovered discrepancies in three of the six core TGCT diagnostic genes, POU5F1, KIT and SOX17 in HPA. DPPA3, CALCA and TDGF1 were presented as potential novel TGCT biomarkers. MGMT was confirmed while RASSF1 and PRSS21 were identified as biomarkers of healthy testicular tissue. Finally, SALL4, SOX17, RASSF1 and PRSS21 dysregulation in the surrounding testicular tissue with complete preserved spermatogenesis of TGCT patients was detected, a potential early sign of neoplastic transformation. We highlight the importance of a multidisciplinary collaborative approach to fully understand the protein landscape of human testis and its pathologies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCells
Numberingvol. 12, no. 14, 12141841
e-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells12141841
URN:NBNurn:nbn:hr:127:136123
Publication2023-07-13
Document URLhttps://www.mdpi.com/2073-4409/12/14/1841
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2023-08-21 08:11:45