Class III malocclusion is orthodontic anomaly in which the lower first molar is located more mesially, so the mesiobuccal cusp of the upper first molar occludes more distally. Dentoalveolar and skeletal anomalies can be the cause of such relationship. Skeletal anomalies include maxillary retrognathism, mandibular prognathism, or their combination. With approximate incidence of about 1% the incidence of class III malocclusion in the white race is significantly lower than in the Asian population where it reaches up to 14%. Class III malocclusion is a developmental condition. Most often, it's not caused by a pathological process, but by a departure from normal development that occurs through the interaction of several factors affecting growth and development. Factors can be genetic and environmental. The diagnosis is made based on a laterolateral cephalogram, or X-ray cephalometry. Class III malocclusion is one of the most challenging orthodontic problems. Class III treatment methods include growth modification while the potential for growth and development still exists, camouflage therapy and combination of orthodontic treatment with orthognathic surgery once growth and development have ceased.