prikaz prve stranice dokumenta Changes in haemostasis and inflammatory markers after mRNA BNT162b2 and vector Ad26.CoV2.S SARS-CoV-2 vaccination
  Download
PDF 412.17 KB
Scientific paper - Original scientific paper
Changes in haemostasis and inflammatory markers after mRNA BNT162b2 and vector Ad26.CoV2.S SARS-CoV-2 vaccination
Thrombosis Research, 228 (2023); 137-144. https://doi.org/10.1016/j.thromres.2023.06.008
Ivanko, I.; Ćelap, I.; Margetić, S.; Marijančević, D.; Josipović, J.; Gaćina, P.

Institutional repository: University of Zagreb School of Dental Medicine Repository

Cite this document

Ivanko, I., Ćelap, I., Margetić, S., Marijančević, D., Josipović, J. & Gaćina, P. (2023). Changes in haemostasis and inflammatory markers after mRNA BNT162b2 and vector Ad26.CoV2.S SARS-CoV-2 vaccination. Thrombosis Research, 228., 137-144. doi: 10.1016/j.thromres.2023.06.008

Ivanko, I., et al. "Changes in haemostasis and inflammatory markers after mRNA BNT162b2 and vector Ad26.CoV2.S SARS-CoV-2 vaccination." Thrombosis Research, vol. 228, 2023, pp. 137-144. https://doi.org/10.1016/j.thromres.2023.06.008

Ivanko, I., I. Ćelap, S. Margetić, D. Marijančević, J. Josipović and P. Gaćina. "Changes in haemostasis and inflammatory markers after mRNA BNT162b2 and vector Ad26.CoV2.S SARS-CoV-2 vaccination." Thrombosis Research 228 (2023): 137-144. https://doi.org/10.1016/j.thromres.2023.06.008

Ivanko, I., et al. (2023) 'Changes in haemostasis and inflammatory markers after mRNA BNT162b2 and vector Ad26.CoV2.S SARS-CoV-2 vaccination', Thrombosis Research, 228, pp. 137-144. doi: 10.1016/j.thromres.2023.06.008

Ivanko I, Ćelap I, Margetić S, Marijančević D, Josipović J, Gaćina P. Changes in haemostasis and inflammatory markers after mRNA BNT162b2 and vector Ad26.CoV2.S SARS-CoV-2 vaccination. Thrombosis Research [Internet]. 2023 August [cited 2024 November 26];228:137-144. doi: 10.1016/j.thromres.2023.06.008

I. Ivanko, I. Ćelap, S. Margetić, D. Marijančević, J. Josipović and P. Gaćina, "Changes in haemostasis and inflammatory markers after mRNA BNT162b2 and vector Ad26.CoV2.S SARS-CoV-2 vaccination", Thrombosis Research, vol. 228, pp. 137-144, August 2023. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:198802. [Accessed: 26 November 2024]

Metadata
Title (english)Changes in haemostasis and inflammatory markers after mRNA BNT162b2 and vector Ad26.CoV2.S SARS-CoV-2 vaccination
AuthorI. Ivanko
AuthorI. Ćelap
AuthorS. Margetić
AuthorD. Marijančević
AuthorJ. Josipović
AuthorP. Gaćina
Author's institutionCatholic University of Croatia
Author's institution(Sestre milosrdnice University Hospital Center)
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Introduction: Reported thromboembolic events after SARS-CoV-2 vaccinations are still raising concerns, predominantly in non-scientific population. The aim of our study was to investigate the differences between haemostasis and inflammatory markers in the subjects vaccinated with mRNA BNT162b2 and vector Ad26.CoV2.S vaccine. Materials and methods: The study included 87 subjects vaccinated with mRNA BNT162b2 and 84 with Ad26. CoV2.S vaccine. All the laboratory parameters (TAT, F 1 + 2, IL-6, CRP, big endothelin-1, platelets, fibrinogen, Ddimers, VWF activity) were investigated for the mRNA vaccine at five (before the first dose, 7 and 14 days after the first and second vaccine dose), and three time points (before the first dose, 7 and 14 days after) for the vector vaccine, respectively. All the markers were measured by well-established laboratory methods. Results: Our results have shown statistically higher CRP levels in the vector group 7 days after vaccination (P = 0.014). Furthermore, study has revealed statistically significant rise in D-dimers (P = 0.004) between tested time points in both vaccine groups but without clinical repercussions. Conclusion: Although statistically significant changes in haemostasis markers have been obtained, they remained clinically irrelevant. Thus, our study implicates that there is no plausible scientific evidence of a significant disruption in the coagulation and inflammatory processes after vaccination with BNT162b2 mRNA and Ad26. CoV2.S vector SARS-CoV-2 vaccines.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleThrombosis Research
Numberingvol. 228, pp. 137-144
p-ISSN0049-3848
DOIhttps://doi.org/10.1016/j.thromres.2023.06.008
URN:NBNurn:nbn:hr:127:198802
Publication2023-08
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S0049384823001809
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-21 10:47:53