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Scientific paper - Original scientific paper
Influence of saliva on the results of global laboratory coagulation tests
Australian Dental Journal, 65 (2020), 3; 205-209. https://doi.org/10.1111/adj.12753
Špiljak, B; Šimunović, L; Lapić, I; Rogić, D; Špalj, S; Vuletić, L

Institutional repository: University of Zagreb School of Dental Medicine Repository

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Špiljak, B., Šimunović, L., Lapić, I., Rogić, D., Špalj, S. & Vuletić, L. (2020). Influence of saliva on the results of global laboratory coagulation tests. Australian Dental Journal, 65. (3), 205-209. doi: 10.1111/adj.12753

Špiljak, B, et al. "Influence of saliva on the results of global laboratory coagulation tests." Australian Dental Journal, vol. 65, no. 3, 2020, pp. 205-209. https://doi.org/10.1111/adj.12753

Špiljak, B, L Šimunović, I Lapić, D Rogić, S Špalj and L Vuletić. "Influence of saliva on the results of global laboratory coagulation tests." Australian Dental Journal 65, no. 3 (2020): 205-209. https://doi.org/10.1111/adj.12753

Špiljak, B., et al. (2020) 'Influence of saliva on the results of global laboratory coagulation tests', Australian Dental Journal, 65(3), pp. 205-209. doi: 10.1111/adj.12753

Špiljak B, Šimunović L, Lapić I, Rogić D, Špalj S, Vuletić L. Influence of saliva on the results of global laboratory coagulation tests. Australian Dental Journal [Internet]. 2020 March 27 [cited 2025 January 12];65(3):205-209. doi: 10.1111/adj.12753

B. Špiljak, L. Šimunović, I. Lapić, D. Rogić, S. Špalj and L. Vuletić, "Influence of saliva on the results of global laboratory coagulation tests", Australian Dental Journal, vol. 65, no. 3, pp. 205-209, March 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:127:172185. [Accessed: 12 January 2025]

Metadata
Title (english)Influence of saliva on the results of global laboratory coagulation tests
AuthorB Špiljak
AuthorL Šimunović
AuthorI Lapić
AuthorD Rogić
AuthorS Špalj
AuthorL Vuletić
Author's institutionUniversity of Rijeka
Author's institution(Clinical Hospital Center Rijeka)
Author's institution(Zagreb University Hispital Center)
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
Author's institutionUniversity of Zagreb
School of Dental Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Dental Medicine
Abstract (english)
Background: Oral wounds inevitably come into contact with saliva which can affect the time needed for bleeding to stop. The influence of saliva can be non-specific, related to dilution of blood, and/or mediated by salivary factors that affect haemostasis directly. The aim of this study was to assess if mixing blood with an individual's saliva would affect the rate of its coagulation measured by global coagulation tests, prothrombin time (PT) and activated partial thromboplastin time (APTT). Methods: The study included 30 healthy non-smoking volunteers. Paired blood and unstimulated saliva samples were obtained from each participant and PT and APTT were determined in blood, blood + saliva and blood + water mixtures. Coagulation tests were performed using the mechanical clot detection method. Results: PT was significantly longer in both blood + saliva and blood + water mixtures compared to blood alone. APTT was significantly longer only in blood + water mixture compared to blood. Conclusions: Similarly prolonged PT in both mixtures suggests that both saliva and water prolong coagulation evenly due to their non-specific effect of blood dilution. The finding that APTT was significantly prolonged only when blood was mixed with water could indicate presence of tissue factor in saliva, however, in a concentration too low to influence the results of PT.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAustralian Dental Journal
Numberingvol. 65, no. 3, pp. 205-209
p-ISSN0045-0421
e-ISSN1834-7819
DOIhttps://doi.org/10.1111/adj.12753
URN:NBNurn:nbn:hr:127:172185
Publication2020-03-27
Document URLhttps://onlinelibrary.wiley.com/doi/10.1111/adj.12753
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-10-22 10:05:58